(S)-10-Hydroxycamptothecin

Name: (S)-10-Hydroxycamptothecin
SKU: A11997

目录号: A11997

Topoisomerase

(S)-10-Hydroxycamptothecin Chemical Structure

CAS NO. 19685-09-7

(S)-10-Hydroxycamptothecin是喜树碱衍生物，它通过在染色体DNA中产生链断裂并诱导细胞凋亡来抑制DNA拓扑异构酶。

库存：现货

规格	价格	数量
50 mg	￥ 420.00
100 mg	￥ 700.00
250 mg	￥ 1,400.00
500 mg	￥ 2,450.00
10mM * 1mL in DMSO	￥ 441.00

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产品详情

生物活性

(S)-10-Hydroxycamptothecin是喜树碱衍生物，它通过在染色体DNA中产生链断裂并诱导细胞凋亡来抑制DNA拓扑异构酶。

靶点信息

DNA topoisomerase I

溶解度 *

In vitro (25°C)	DMSO	Warmed: 7 mg/mL (19.21 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.45 mL	137.23 mL	274.46 mL
0.5 mM	5.49 mL	27.45 mL	54.89 mL
1 mM	2.74 mL	13.72 mL	27.45 mL
5 mM	0.55 mL	2.74 mL	5.49 mL

*The above data is based on the productmolecular weight 364.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11997
作用机制	Inhibitor (抑制剂)
M. Wt	364.35
Formula	C20H16N2O5
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	19685-09-7
Synonyms	HCPT;SN38;Ampule;NSC 107124;HYDROCAMPTOTHECINE;HYDROXYCAMPTOTHECIN;
SMILES	CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O