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S-Ruxolitinib

S-Ruxolitinib

Name: S-Ruxolitinib
SKU: A14955

目录号: A14955

JAK 抑制剂

S-Ruxolitinib Chemical Structure

CAS NO. 941685-37-6

S-Ruxolitinib是INCB018424的手性化合物，是一种有效且选择性的小分子Janus激酶1（JAK1）和JAK2抑制剂。

库存：现货

规格	价格	数量
5 mg	￥ 910.00
10 mg	￥ 1,400.00
50 mg	￥ 3,850.00

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生物活性

S-Ruxolitinib是INCB018424的手性化合物，是一种有效且选择性的小分子Janus激酶1（JAK1）和JAK2抑制剂。

Targets

Target	Value
JAK2	IC50: 2.8nM
JAK1	IC50: 3.3nM
TYK2	IC50: 19nM
JAK3	IC50: 428nM
Chk2	IC50: >1μM
c-Met	IC50: >10μM

溶解度 *

In vitro (25°C)	DMSO	59 mg/mL (192.57 mM)
	Water	5 mg/mL (16.32 mM)
	Ethanol	59 mg/mL (192.57 mM)
In vivo	0.5% CMC+0.25% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.64 mL	163.2 mL	326.4 mL
0.5 mM	6.53 mL	32.64 mL	65.28 mL
1 mM	3.26 mL	16.32 mL	32.64 mL
5 mM	0.65 mL	3.26 mL	6.53 mL

*The above data is based on the productmolecular weight 306.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14955
作用机制	Inhibitor (抑制剂)
M. Wt	306.37
Formula	C17H18N6
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	941685-37-6
Synonyms	INCB018424
SMILES	C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3