Salubrinal
Salubrinal 是一种细胞渗透性、选择性抑制剂，专门抑制细胞内磷酸酶复合体，这些复合体会去磷酸化真核翻译起始因子2亚基α（eIF2α）。它能保护细胞免受内质网应激诱导的凋亡（EC50 约为 15 μM）。
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生物活性
| Discription | Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM). | |||||
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产品信息
| 目录号 | A12676 |
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| 分子式 | C21H17N4OSCl3 |
| 分子量 | 479.81 |
| CAS号 | 405060-95-9 |
| SMILES | C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 86 mg/mL (179.23 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.84 mL | 104.21 mL | 208.42 mL |
| 0.5 mM | 4.17 mL | 20.84 mL | 41.68 mL |
| 1 mM | 2.08 mL | 10.42 mL | 20.84 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.17 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 405060-95-9 | 405060-95-9 供应商 | 405060-95-9 花费 | 405060-95-9 生产商 | 订购 405060-95-9 | 405060-95-9 代理商