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Salubrinal是细胞磷酸酶复合物的可渗透细胞的选择性抑制剂，可将真核翻译起始因子2亚基α（eIF2α）磷酸化。保护细胞免受内质网应激诱导的细胞凋亡（EC50?15 μM）。
靶点信息
| eIF2α (Cell-free assay) | ||||
| In vitro | DMSO | 86 mg/mL (179.23 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.84 mL | 104.21 mL | 208.42 mL |
| 0.5 mM | 4.17 mL | 20.84 mL | 41.68 mL |
| 1 mM | 2.08 mL | 10.42 mL | 20.84 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.17 mL |
*The above data is based on the productmolecular weight 479.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12676 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 479.81 |
| Formula | C21H17N4OSCl3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 405060-95-9 |
| SMILES | C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3 |
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