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SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.69 mL | 113.43 mL | 226.86 mL |
| 0.5 mM | 4.54 mL | 22.69 mL | 45.37 mL |
| 1 mM | 2.27 mL | 11.34 mL | 22.69 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
*The above data is based on the productmolecular weight 440.793. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17237 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 440.793 |
| Formula | C21H24Cl3N3O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1333207-63-8 |
| Synonyms | SAR-7334; SAR 7334; SAR7334 |
| SMILES | N#CC1=CC=C(O[C@H]2[C@H](N3C[C@H](N)CCC3)CC4=C2C=CC=C4)C(Cl)=C1.[H]Cl.[H]Cl |
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