SAR125844
目录号: A21094
MET 抑制剂
SAR125844 是一种强效、高度选择性、可逆的、与ATP竞争的 MET 受体酪氨酸激酶 (RTK) 抑制剂，其 IC50 为 4.2 nM。在基于细胞的实验中显示出对 MET 自磷酸化的抑制作用。
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生物活性
| Discription | SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays. | |||||
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| Cell Research |
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产品信息
| 目录号 | A21094 |
|---|---|
| 分子式 | C25H23FN8O2S2 |
| 分子量 | 550.63 |
| CAS号 | 1116743-46-4 |
| SMILES | O=C(NCCN1CCOCC1)NC2=NC3=CC=C(SC4=NN=C5C=CC(C6=CC=C(F)C=C6)=NN54)C=C3S2 |
| 其他名称 | SAR 125844, SAR-125844 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 11 mg/mL (19.97 mM) | |
| Water | <1 mg/mL | ||
| Ethanol | <1 mg/mL | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.16 mL | 90.81 mL | 181.61 mL |
| 0.5 mM | 3.63 mL | 18.16 mL | 36.32 mL |
| 1 mM | 1.82 mL | 9.08 mL | 18.16 mL |
| 5 mM | 0.36 mL | 1.82 mL | 3.63 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1116743-46-4 | 1116743-46-4 供应商 | 1116743-46-4 花费 | 1116743-46-4 生产商 | 订购 1116743-46-4 | 1116743-46-4 代理商