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SAR125844

产品详情

SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays.

溶解度 *

In vitro	DMSO	11 mg/mL (19.97 mM)
	Water	<1 mg/mL
	Ethanol	<1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.16 mL	90.81 mL	181.61 mL
0.5 mM	3.63 mL	18.16 mL	36.32 mL
1 mM	1.82 mL	9.08 mL	18.16 mL
5 mM	0.36 mL	1.82 mL	3.63 mL

*The above data is based on the productmolecular weight 550.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A21094
作用机制	Inhibitor (抑制剂)
M. Wt	550.63
Formula	C25H23FN8O2S2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1116743-46-4
Synonyms	SAR 125844, SAR-125844
SMILES	O=C(NCCN1CCOCC1)NC2=NC3=CC=C(SC4=NN=C5C=CC(C6=CC=C(F)C=C6)=NN54)C=C3S2