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SAR156497是一种选择性选择性的Aurora A，B和C抑制剂，具有体外和体内功效，IC50分别为0.5 nM（Aurora A），1 nM（Aurora B/incenp），3 nM（Aurora C/incenp）SAR156497组合具有很高的体外药效，具有令人满意的代谢稳定性，并且对CYP3A4和PDE3的抑制作用有限。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.34 mL | 106.72 mL | 213.45 mL |
| 0.5 mM | 4.27 mL | 21.34 mL | 42.69 mL |
| 1 mM | 2.13 mL | 10.67 mL | 21.34 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
*The above data is based on the productmolecular weight 468.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14382 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 468.5 |
| Formula | C27H24N4O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1256137-14-0 |
| Synonyms | SAR-156497, SAR 156497 |
| SMILES | O=C(C1=C2NC3=C(C(CCC3)=O)[C@@H](C4=CC=CC(OC5=NC6=CC=CC=C6N5)=C4)C2=CN1)OCC |
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