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SAR156497

目录号: A14382
Aurora Kinase 抑制剂
SAR156497 是一种极具选择性的 Aurora ABC 抑制剂,在体外和体内均显示出有效性,其半抑制浓度(IC50)分别为 0.5 nM(Aurora A)、1 nM(Aurora B / incenp)、3 nM(Aurora C / incenp)。SAR156497 结合了高体外活性、满意的代谢稳定性,并且对 CYP3A4PDE3 抑制有限。
Grouped product items
规格 价格 库存 数量
5mg
¥3,500.00
现货
10mg
¥5,600.00
现货
25mg
¥10,605.00
现货
50mg
¥13,825.00
现货
100mg
¥17,465.00
现货
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生物活性
Discription SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A), 1 nM (Aurora B / incenp), 3 nM (Aurora C / incenp) respectively SAR156497 combines high in vitro potency with satisfactory metabolic stability and limited CYP3A4 and PDE3 inhibition.
产品信息
目录号 A14382
分子式 C27H24N4O4
分子量 468.5
CAS号 1256137-14-0
SMILES O=C(C1=C2NC3=C(C(CCC3)=O)[C@@H](C4=CC=CC(OC5=NC6=CC=CC=C6N5)=C4)C2=CN1)OCC
其他名称 SAR-156497, SAR 156497
储存条件

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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