SAR405
目录号: A21345
PI3KC3 isoform Vps34 inhibitor
SAR405 是一种首创的、选择性的、与ATP竞争的 PI3K III 类（PI3KC3）亚型 Vps34 抑制剂（IC50=1.2 nM; Kd=1.5 nM）。
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生物活性
| Discription | SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PI3KC3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM). | |||||
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| Cell Research |
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产品信息
| 目录号 | A21345 |
|---|---|
| 分子式 | C19H21ClF3N5O2 |
| 分子量 | 443.85 |
| CAS号 | 1523406-39-4 |
| SMILES | O=C1N(C2=NC(N3[C@H](C)COCC3)=C1)CC[C@@H](C(F)(F)F)N2CC4=CC(Cl)=CN=C4 |
| 其他名称 | SAR 405, SAR-405 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | Warmed: 76 mg/mL (171.22 mM) | |
| Water | Insoluble | ||
| Ethanol | 76 mg/mL (171.22 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 3 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.53 mL | 112.65 mL | 225.3 mL |
| 0.5 mM | 4.51 mL | 22.53 mL | 45.06 mL |
| 1 mM | 2.25 mL | 11.27 mL | 22.53 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.51 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1523406-39-4 | 1523406-39-4 供应商 | 1523406-39-4 花费 | 1523406-39-4 生产商 | 订购 1523406-39-4 | 1523406-39-4 代理商