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SB202190是p38 MAP激酶的高度选择性，有效和细胞渗透性抑制剂。
靶点信息
| p38α (Cell-free assay) | p38β (Cell-free assay) | |||
| 50 nM | 100 nM |
| In vitro (25°C) | DMSO | 62 mg/mL (187.12 mM) | |
| Water | Insoluble | ||
| Ethanol | 11 mg/mL (33.19 mM) | ||
| In vivo | 5%DMSO+40%PEG300+5%Tween80+50%H2O | 7 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.18 mL | 150.92 mL | 301.84 mL |
| 0.5 mM | 6.04 mL | 30.18 mL | 60.37 mL |
| 1 mM | 3.02 mL | 15.09 mL | 30.18 mL |
| 5 mM | 0.6 mL | 3.02 mL | 6.04 mL |
*The above data is based on the productmolecular weight 331.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10823 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 331.3 |
| Formula | C20H14N3OF |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 152121-30-7 |
| Synonyms | SB-202190, SB202190 |
| SMILES | C1=CC(=O)C=CC1=C2NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F |
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