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SB 239063

目录号: A11562
p38 MAPK 抑制剂
SB 239063 是一种强效且选择性的 p38 MAP激酶抑制剂(对 p38α 的 IC50 = 44 nM)。SB 239063 对 ERK、JNK1 及其他激酶显示出超过 220 倍的选择性;比 SB 203580 选择性高出约 3 倍。SB 239063 在体内口服给药后可以减少炎症性细胞因子的产生,并具有神经保护作用。
Grouped product items
规格 价格 库存 数量
1mg
¥245.00
现货
2mg
¥350.00
现货
5mg
¥560.00
现货
10mg
¥1,085.00
现货
25mg
¥2,065.00
现货
50mg
¥3,640.00
现货
100mg
¥5,320.00
现货
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生物活性
Discription SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.
Targets
Target Value
产品信息
目录号 A11562
分子式 C20H21FN4O2
分子量 368.4
CAS号 193551-21-2
SMILES COC1=NC=CC(=N1)C2=C(N=CN2C3CCC(CC3)O)C4=CC=C(C=C4)F
其他名称 SB239063, SB-239063
储存条件

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据
In vitro (25°C) DMSO 59 mg/mL (160.15 mM)
Water Insoluble
Ethanol Warmed: 7 mg/mL (19 mM)
In vivo 5% DMSO+30% PEG 300+ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.14 mL 135.72 mL 271.44 mL
0.5 mM 5.43 mL 27.14 mL 54.29 mL
1 mM 2.71 mL 13.57 mL 27.14 mL
5 mM 0.54 mL 2.71 mL 5.43 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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