微信关注
Total item
Cart Subtotal
￥ 0.00 产品详情
SB 239063是一种强效选择性p38 MAPKα/β抑制剂(p38α的IC50=44 nM)。SB 239063对ERK, JNK1和其他激酶的选择性超过220倍；比SB 203580的选择性高约3倍。SB 239063减少炎症细胞因子的产生，并在体内口服后具有神经保护作用。
靶点信息
| p38α | p38β | |||
| 44 nM | 44 nM |
| In vitro (25°C) | DMSO | 59 mg/mL (160.15 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 7 mg/mL (19 mM) | ||
| In vivo | 5% DMSO+30% PEG 300+ddH2O | 3 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.14 mL | 135.72 mL | 271.44 mL |
| 0.5 mM | 5.43 mL | 27.14 mL | 54.29 mL |
| 1 mM | 2.71 mL | 13.57 mL | 27.14 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.43 mL |
*The above data is based on the productmolecular weight 368.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11562 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 368.4 |
| Formula | C20H21FN4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 193551-21-2 |
| Synonyms | SB239063, SB-239063 |
| SMILES | COC1=NC=CC(=N1)C2=C(N=CN2C3CCC(CC3)O)C4=CC=C(C=C4)F |
产品标签
Product Questions
Product Questions
No Questions
您还可能对下列产品感兴趣
SKF 86002 Dihydrochloride
SKF 86002 Dihydrochloride是p38 MAP激酶的抑制剂（IC50 = 0.1-1 uM）。有效抑制人单核细胞中LPS诱导的IL-1和TNF-α的产…
Talmapimod (SCIO-469)
Talmapimod (SCIO-469)是一种具有ATP竞争性的选择性p38抑制剂（体外p38α的IC50 = 9 nM）。
Pexmetinib (ARRY-614)
Pexmetinib (ARRY-614)是通过双重抑制p38促分裂原活化蛋白激酶（MAPK）和Tie2/Tek受体酪氨酸激酶，其在HEK-293细胞…
Asiaticoside
Asiaticoside是植物积雪草的活性化学成分。积雪草苷用于研究伤口和烧伤的潜在治疗方法。
Keywords:购买 SB 239063 | SB 239063 供应商 | 订购 SB 239063 | SB 239063 价格 | SB 239063 生产商 | 订单 SB 239063 | SB 239063 代理商 | 购买 193551-21-2| 193551-21-2 供应商 | 订购 193551-21-2 | 193551-21-2 价格 | 193551-21-2 生产商 | 订单 193551-21-2 | 193551-21-2 代理商|buy SB 239063 | SB 239063 Supplier | purchase SB 239063 | SB 239063 cost | SB 239063 manufacturer | order SB 239063 | SB 239063 distributor | buy 193551-21-2| 193551-21-2 Supplier | purchase 193551-21-2 | 193551-21-2 cost | 193551-21-2 manufacturer | order 193551-21-2 | 193551-21-2 distributor