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SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.55 mL | 97.75 mL | 195.51 mL |
| 0.5 mM | 3.91 mL | 19.55 mL | 39.1 mL |
| 1 mM | 1.96 mL | 9.78 mL | 19.55 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.91 mL |
*The above data is based on the productmolecular weight 511.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21353 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 511.49 |
| Formula | C28H32Cl2N4O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1226917-67-4 |
| Synonyms | SB-277011A dihydrochloride, SB277011, SB 277011, SB 277011A, SB277011A |
| SMILES | O=C(C1=CC=NC2=CC=CC=C12)N[C@H]3CC[C@H](CCN4CC5=C(C=C(C#N)C=C5)CC4)CC3.[H]Cl.[H]Cl |
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