SB-408124

Name: SB-408124
SKU: A11567

目录号: A11567

OX Receptor 拮抗剂

SB-408124 Chemical Structure

CAS NO. 288150-92-5

SB-408124是一种选择性的非肽orexin OX1受体拮抗剂(人OX1和OX2受体的Kb值分别为21.7和1405 nM)。体内口服后阻断orexin-A诱导的修饰。

库存：现货

规格	价格	数量
10 mg	￥ 560.00
25 mg	￥ 1,120.00
50 mg	￥ 1,960.00
100 mg	￥ 3,500.00
10mM * 1mL in DMSO	￥ 616.00

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生物活性

SB-408124是一种选择性的非肽orexin OX1受体拮抗剂(人OX1和OX2受体的Kb值分别为21.7和1405 nM)。体内口服后阻断orexin-A诱导的修饰。

靶点信息

OX1 (membrane)	OX1 (whole cell)
27 nM(Ki)	57 nM(Ki)

溶解度 *

In vitro (25°C)	DMSO	35 mg/mL (98.2 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.06 mL	140.3 mL	280.61 mL
0.5 mM	5.61 mL	28.06 mL	56.12 mL
1 mM	2.81 mL	14.03 mL	28.06 mL
5 mM	0.56 mL	2.81 mL	5.61 mL

*The above data is based on the productmolecular weight 356.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11567
作用机制	Antagonist (拮抗剂)
M. Wt	356.37
Formula	C19H18F2N4O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	288150-92-5
Synonyms	SB408124, SB 408124
SMILES	CC1=NC2=C(C=C(C=C2C(=C1)NC(=O)NC3=CC=C(C=C3)N(C)C)F)F