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SB 415286是一种有效且具有选择性的细胞渗透性ATP竞争性GSK3α抑制剂，IC50值为78 nM（与GSK3β相似的效价），Ki值为31 nM。
靶点信息
| GSK-3α | GSK-3β | |||
| 78 nM | ~78 nM |
| In vitro | DMSO | 63 mg/mL (175.13 mM) | |
| Water | Insoluble | ||
| Ethanol | 63 mg/mL (175.13 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.8 mL | 139 mL | 278.01 mL |
| 0.5 mM | 5.56 mL | 27.8 mL | 55.6 mL |
| 1 mM | 2.78 mL | 13.9 mL | 27.8 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.56 mL |
*The above data is based on the productmolecular weight 359.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11061 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 359.7 |
| Formula | C16H10ClN3O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 264218-23-7 |
| Synonyms | SB-415286, SB415286 |
| SMILES | C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-] |
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