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SB525334是转化生长因子-β受体I（ALK5，TGF-βRI）的选择性抑制剂 (IC50 = 14.3 nM)。抑制TGF-β1诱导的smad2/3核定位和TGF-βRI诱导的肾细胞mRNA表达。
靶点信息
| TGFβR1(ALK5) (Cell-free assay) | ||||
| 14.3 nM |
| In vitro (25°C) | DMSO | 67 mg/mL (195.09 mM) | |
| Water | Insoluble | ||
| Ethanol | 67 mg/mL (195.09 mM) | ||
| In vivo | 5% DMSO+corn oil | 19 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.12 mL | 145.6 mL | 291.21 mL |
| 0.5 mM | 5.82 mL | 29.12 mL | 58.24 mL |
| 1 mM | 2.91 mL | 14.56 mL | 29.12 mL |
| 5 mM | 0.58 mL | 2.91 mL | 5.82 mL |
*The above data is based on the productmolecular weight 343.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10827 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 343.4 |
| Formula | C21H21N5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 356559-20-1 |
| Synonyms | SB-525334, SB525334 |
| SMILES | CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3 |
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