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SBE 13 HCl是PLK1的选择性抑制剂，对于PLK1，PLK3和PLK2，IC 50值分别为200pM，875nM和66μM。
靶点信息
| PLK1 | PLK3 | PLK2 | ||
| 200 pM | 875 nM | >66 μM |
| In vitro | DMSO | 90 mg/mL (187.73 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.86 mL | 104.3 mL | 208.59 mL |
| 0.5 mM | 4.17 mL | 20.86 mL | 41.72 mL |
| 1 mM | 2.09 mL | 10.43 mL | 20.86 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.17 mL |
*The above data is based on the productmolecular weight 479.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14426 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 479.4 |
| Formula | C24H27ClN2O4.HC |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1052532-15-6 |
| Synonyms | SBE-13, SBE 13 |
| SMILES | COC1=C(C=C(C=C1)CCNCC2=CC(=C(C=C2)OCC3=CN=C(C=C3)Cl)OC)OC.Cl |
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