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SBI-0206965是一种有效的，选择性的且细胞可渗透的自噬激酶ULK1抑制剂，对于ULK1激酶活性，IC50为108 nM；对于高度相关的激酶ULK2，IC50为711 nM。
| In vitro | DMSO | 90 mg/mL (183.92 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 9 mg/mL (18.39 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.44 mL | 102.18 mL | 204.37 mL |
| 0.5 mM | 4.09 mL | 20.44 mL | 40.87 mL |
| 1 mM | 2.04 mL | 10.22 mL | 20.44 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.09 mL |
*The above data is based on the productmolecular weight 489.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15795 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 489.32 |
| Formula | C21H21BrN4O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1884220-36-3 |
| Synonyms | SBI 0206965, SBI0206965 |
| SMILES | CNC(=O)C1=CC=CC=C1OC2=NC(=NC=C2Br)NC3=CC(=C(C(=C3)OC)OC)OC |
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