SCH 900776 (MK-8776)

Name: SCH 900776 (MK-8776)
SKU: A11167
Price: 280 CNY
Rating: 5 (5 reviews)

目录号: A11167

Chk1 抑制剂

5 篇发表文献

SCH900776 是一种针对细胞周期检查点激酶 1（Chk1）的药物，具有潜在的放射增敏和化疗增敏活性。它特异性地结合并抑制 Chk1，这可能导致肿瘤细胞绕过 Chk1 依赖的细胞周期在 S 和 G2/M 阶段停滞，以进行 DNA 修复，然后进入有丝分裂；因此，肿瘤细胞可能对电离辐射和烷化化疗药物的 DNA 损伤效应变得敏感。

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Grouped product items
规格	价格	库存
1mg	¥280.00	现货
2mg	¥455.00	现货
5mg	¥595.00	现货
10mg	¥1,085.00	现货
25mg	¥2,030.00	现货
50mg	¥3,115.00	现货
100mg	¥4,830.00	现货
*10mM 1mL in DMSO**	¥840.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用SCH 900776 (MK-8776)发表的5篇文献

Hong Yang, .et al. , Research Square, 2022, May 9th

Motofumi Suzuki, .et al. , Int J Radiat Oncol Biol Phys, 2021, May 25;S0360-3016(21)00361-8 PMID: 34112559

Min Wu, .et al. , Haematologica, 2019, 104 PMID: 30975911

Permata TBM, .et al. , Oncogene, 2019, Feb 12 PMID: 30755733

Hiro Sato, .et al. , Nat Commun, 2017, 8: 1751 PMID: 29170499

生物活性

Discription

SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

Targets

Target	Value

产品信息

目录号	A11167
分子式	C15H18BrN7
分子量	376.25
CAS号	891494-63-6
SMILES	NC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13
其他名称	SCH-900776, MK-8776, MK8776, MK 8776
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	3 mg/mL (7.97 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% propylene glycol	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.58 mL	132.89 mL	265.78 mL
0.5 mM	5.32 mL	26.58 mL	53.16 mL
1 mM	2.66 mL	13.29 mL	26.58 mL
5 mM	0.53 mL	2.66 mL	5.32 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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