Semagacestat (LY450139)

Name: Semagacestat (LY450139)
SKU: A10836

目录号: A10836

Gamma-secretase 抑制剂

Product Citations (1)

Semagacestat (LY450139) Chemical Structure

CAS NO. 425386-60-3

Semagacestat (LY450139)是一种针对Aβ42，Aβ40和Aβ38的γ-分泌酶阻滞剂，IC50分别为10.9 nM，12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导，IC50为14.1 nM。

库存：现货

规格	价格	数量
5 mg	￥ 441.00
10 mg	￥ 749.00
50 mg	￥ 2,205.00
100 mg	￥ 7,497.00
10mM * 1mL in DMSO	￥ 840.00

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生物活性

Semagacestat (LY450139)是一种针对Aβ42，Aβ40和Aβ38的γ-分泌酶阻滞剂，IC50分别为10.9 nM，12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导，IC50为14.1 nM。

靶点信息

γ secretase(Aβ42) (H4 human glioma cells)	γ secretase(Aβ38) (H4 human glioma cells)	γ secretase(Aβ40) (H4 human glioma cells)	Notch (H4 human glioma cells)
10.9 nM	12.0 nM	12.1 nM	14.1 nM

溶解度 *

In vitro (25°C)	DMSO	66 mg/mL (182.6 mM)
	Water	Insoluble
	Ethanol	38 mg/mL (105.13 mM)
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.67 mL	138.35 mL	276.7 mL
0.5 mM	5.53 mL	27.67 mL	55.34 mL
1 mM	2.77 mL	13.84 mL	27.67 mL
5 mM	0.55 mL	2.77 mL	5.53 mL

*The above data is based on the productmolecular weight 361.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10836
作用机制	Inhibitor (抑制剂)
M. Wt	361.4
Formula	C19H27N3O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	425386-60-3
Synonyms	LY-450139
SMILES	C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2CCN(C1=O)C)NC(=O)[C@H](C(C)C)O