产品详情

生物活性

SGI 1027是DNMT抑制剂，对DNMT1，DNMT3A和DNMT3B的IC50分别为6、8、7.5 uM。

靶点信息

DNMT1 (Cell-free assay)	DNMT3B (Cell-free assay)	DNMT3A (Cell-free assay)
6 μM	7.5 μM	8 μM

溶解度 *

In vitro (25°C)	DMSO	85 mg/mL (184.17 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.67 mL	108.34 mL	216.68 mL
0.5 mM	4.33 mL	21.67 mL	43.34 mL
1 mM	2.17 mL	10.83 mL	21.67 mL
5 mM	0.43 mL	2.17 mL	4.33 mL

*The above data is based on the productmolecular weight 461.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14120
作用机制	Inhibitor (抑制剂)
M. Wt	461.52
Formula	C27H23N7O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1020149-73-8
Synonyms	SGI-1027, SGI1027
SMILES	CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54