产品详情

生物活性

SGX-523是一种口服生物可利用的小分子，与c-Met蛋白或HGFR特异性结合，可防止HGF结合并破坏MET信号通路。

Targets

Target	Value
c-Met	IC50: 4nM
B-Raf(V599E)	IC50: >7μM
C-Raf	IC50: >7μM
Abl	IC50: >7μM
p38α	IC50: >7μM
Abl1(Y253F)	IC50: >7μM

溶解度 *

In vitro (25°C)	DMSO	Warmed: 3 mg/mL (8.34 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose+0.2% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.82 mL	139.12 mL	278.24 mL
0.5 mM	5.56 mL	27.82 mL	55.65 mL
1 mM	2.78 mL	13.91 mL	27.82 mL
5 mM	0.56 mL	2.78 mL	5.56 mL

*The above data is based on the productmolecular weight 359.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10839
作用机制	Inhibitor (抑制剂)
M. Wt	359.4
Formula	C18H13N7S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1022150-57-7
Synonyms	SGX523
SMILES	CN1C=C(C=N1)C2=NN3C(=NN=C3SC4=CC5=C(C=C4)N=CC=C5)C=C2