Sirtuins

Inhibitory Selectivity

Catalog No.	Inhibitor Name	SIRT1	SIRT2	SIRT3	Sirtuin	Other
A10377	Selisistat (EX 527)	****
A12226	Sirtinol	*	**
A15902	SirReal2		****
A14221	Splitomicin				**
A14225	AGK2		***
A12305	Tenovin-6	***		*		p53

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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SIRT-IN-1

Catalog No. A20962
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SIRT1/2/3 inhibitor

SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively. 了解更多

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SIRT-IN-2

Catalog No. A20961
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SIRT1/2/3 inhibitor

SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively. 了解更多

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Salermide

Catalog No. A12263
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Sirt1/Sirt2 inhibitor

Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death. 了解更多

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Cambinol

Catalog No. A12381
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SIRT1 and SIRT2 inhibitor

Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively. 了解更多

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3-TYP

Catalog No. A17144
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SIRT3 抑制剂

3-TYP是SIRT3抑制剂。了解更多

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Thiomyristoyl

Catalog No. A17166
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SIRT2 抑制剂

Thiomyristoyl是一种有效的特异性SIRT2抑制剂，IC50为28 nM。了解更多

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OSS-128167

Catalog No. A17048
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SIRT 6 抑制剂

OSS-128167，也称为SIRT6-IN-1，是一种有效的选择性SIRT 6抑制剂，IC50值为89 μM。了解更多

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Sirtinol

Catalog No. A12226
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sirtuin 抑制剂

Sirtinol是Sirtinol NAD依赖组蛋白去乙酰化酶的细胞渗透性特异性抑制剂。在无细胞分析中，它是一种特异性SIRT1和SIRT2抑制剂，IC50分别为131 μM和38 μM。了解更多

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AK-1

Catalog No. A14370
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SIRT2 抑制剂

AK-1比SIRT1和SIRT3选择性抑制SIRT2。了解更多

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AGK2

Catalog No. A14225
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SIRT2 抑制剂

AGK2是一种有效的选择性SIRT2抑制剂，IC50为3.5μM。了解更多

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Inauhzin

Catalog No. A12527
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SIRT1 抑制剂

Inauhzin是一种有效的SirT1/IMPDH2 的双重抑制剂，可通过抑制SIRT1活性有效地重新激活p53，促进人类癌细胞的p53依赖性凋亡，而不会引起明显的遗传毒性应激。了解更多

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AK-7

Catalog No. A12904
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SIRT2 抑制剂

AK-7是SIRT2的细胞和脑渗透抑制剂（IC50 = 15.5 μM）。了解更多

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SirReal2

Catalog No. A15902
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Selective SIRT2 抑制剂

SirReal2是一种有效的、同型选择性Sirt2抑制剂，IC50为140 nM。了解更多

Product Citations (1)

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- Yang Li, .et al. SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism, Neoplasia, 2018, Jul; 20(7): 745-756 PMID: 29925042
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EX 527 (Selisistat)

Catalog No. A10377
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SIRT1 抑制剂

EX 527 (Selisistat)是一种有效的选择性SIRT1 III类组蛋白脱乙酰基酶抑制剂，在无细胞分析中的IC50为38 nM。了解更多

Product Citations (5)

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- Takeshi Nakamura, .et al. Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells, Shimane Journal of Medical Science, 2022, 38 (2), 59-66
- Bugga Paramesha, .et al. Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function, Antioxidants (Basel), 2021, Feb 24;10(3):338 PMID: 33668369
- Wenhui Yao, .et al. Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARα/Sirt1/AMPKα pathway, J Cell Physiol, 2020, 07 August
- Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
- Yoshikawa A, .et al. Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice, J Neurochem, 2015, Feb;132(3):342-53 PMID: 25351847