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Sivelestat

目录号: A14184

Neutrophil elastase 抑制剂

Sivelestat

Sivelestat Chemical Structure

CAS NO. 127373-66-4

Sivelestat是一种可渗透细胞的磺酰苯胺化合物，可作为中性粒细胞弹性蛋白酶的强效，底物竞争性和高度特异性抑制剂（大鼠，兔，仓鼠，人类和小鼠白细胞弹性蛋白酶的IC50 = 19-49 nM）。

库存： 现货

规格 价格 数量
10 mg
￥ 455.00
25 mg
￥ 910.00
50 mg
￥ 1,680.00
或
Warning 产品仅用于科学研究，不针对患者销售，望谅解.
产品详情

生物活性

Sivelestat是一种可渗透细胞的磺酰苯胺化合物，可作为中性粒细胞弹性蛋白酶的强效，底物竞争性和高度特异性抑制剂（大鼠，兔，仓鼠，人类和小鼠白细胞弹性蛋白酶的IC50 = 19-49 nM）。
靶点信息
neutrophil elastase

溶解度 *

In vitro (25°C) DMSO 76 mg/mL (174.92 mM)
Water Insoluble
Ethanol 76 mg/mL (174.92 mM)
In vivo 5% DMSO+40% PEG 300+5% Tween 80+ddH2O 21 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.02 mL 115.09 mL 230.17 mL
0.5 mM 4.6 mL 23.02 mL 46.03 mL
1 mM 2.3 mL 11.51 mL 23.02 mL
5 mM 0.46 mL 2.3 mL 4.6 mL

*The above data is based on the productmolecular weight 434.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号 A14184
作用机制 Inhibitor (抑制剂)
M. Wt 434.46
Formula C20H22N2O7S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No. 127373-66-4
Synonyms Elastase Inhibitor IV
SMILES CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O

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