Sivelestat
目录号: A14184
Neutrophil elastase 抑制剂
Sivelestat 是一种可渗透细胞的磺胺类化合物，作为一种强效、底物竞争性且高度特异性的中性粒细胞弹性蛋白酶抑制剂（IC50 = 19-49 nM，适用于大鼠、兔、仓鼠、人类和小鼠的白细胞弹性蛋白酶）。
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重要通知：仅供研究使用。我们不向患者销售。
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生物活性
| Discription | Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). | |||||
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产品信息
| 目录号 | A14184 |
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| 分子式 | C20H22N2O7S |
| 分子量 | 434.46 |
| CAS号 | 127373-66-4 |
| SMILES | CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O |
| 其他名称 | Elastase Inhibitor IV |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 76 mg/mL (174.92 mM) | |
| Water | Insoluble | ||
| Ethanol | 76 mg/mL (174.92 mM) | ||
| In vivo | 5% DMSO+40% PEG 300+5% Tween 80+ddH2O | 21 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.02 mL | 115.09 mL | 230.17 mL |
| 0.5 mM | 4.6 mL | 23.02 mL | 46.03 mL |
| 1 mM | 2.3 mL | 11.51 mL | 23.02 mL |
| 5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 127373-66-4 | 127373-66-4 供应商 | 127373-66-4 花费 | 127373-66-4 生产商 | 订购 127373-66-4 | 127373-66-4 代理商