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SKF 86002 Dihydrochloride是p38 MAP激酶的抑制剂（IC50 = 0.1-1 uM）。有效抑制人单核细胞中LPS诱导的IL-1和TNF-α的产生（IC50 = 1 uM）。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.01 mL | 135.04 mL | 270.07 mL |
| 0.5 mM | 5.4 mL | 27.01 mL | 54.01 mL |
| 1 mM | 2.7 mL | 13.5 mL | 27.01 mL |
| 5 mM | 0.54 mL | 2.7 mL | 5.4 mL |
*The above data is based on the productmolecular weight 370.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11101 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 370.27 |
| Formula | C16H12FN3S.2HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 116339-68-5 |
| Synonyms | SKF86002 Dihydrochloride |
| SMILES | C1CSC2=NC(=C(N21)C3=CC=NC=C3)C4=CC=C(C=C4)F.Cl.Cl |
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