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SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.
| In vitro (25°C) | DMSO | 50 mg/mL (174.64 mM) | |
| Water | Insoluble | ||
| Ethanol | 50 mg/mL (174.64 mM) | ||
| In vivo | 2% DMSO+40% PEG 300+2% Tween 80+ddH2O | 6 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.93 mL | 174.65 mL | 349.3 mL |
| 0.5 mM | 6.99 mL | 34.93 mL | 69.86 mL |
| 1 mM | 3.49 mL | 17.46 mL | 34.93 mL |
| 5 mM | 0.7 mL | 3.49 mL | 6.99 mL |
*The above data is based on the productmolecular weight 286.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16707 |
|---|---|
| 作用机制 | Agonist (激动剂) |
| M. Wt | 286.29 |
| Formula | C14H14N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 909089-13-0 |
| Synonyms | SKL 2001, SKL-2001 |
| SMILES | O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=CN=C3 |
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