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SIM-4a是一种Pim激酶抑制剂，可通过激活AMPK来阻断mTORC1的活性。 通常对Pim-2有效，不会显着抑制任何其他丝氨酸/苏氨酸或酪氨酸激酶。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 36.6 mL | 183.02 mL | 366.03 mL |
| 0.5 mM | 7.32 mL | 36.6 mL | 73.21 mL |
| 1 mM | 3.66 mL | 18.3 mL | 36.6 mL |
| 5 mM | 0.73 mL | 3.66 mL | 7.32 mL |
*The above data is based on the productmolecular weight 273.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11945 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 273.2 |
| Formula | C11H6F3NO2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 327033-36-3 |
| Synonyms | SMI4a |
| SMILES | O=C(NC/1=O)SC1=C/C2=CC=CC(C(F)(F)F)=C2 |
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