SNIPER(ABL)-039

Name: SNIPER(ABL)-039
SKU: A19588
Price: 2240 CNY
Rating: 5 (288 reviews)

目录号: A19588

SNIPER(ABL)-039，通过连接剂将Dasatinib（ABL抑制剂）与LCL161衍生物（IAP配体）结合，能够以DC50为10 nM的效果降低BCR-ABL蛋白水平。其IC50分别为ABL 0.54 nM、cIAP1 10 nM、cIAP2 12 nM、XIAP 50 nM。

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Data Sheet

SDS

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生物活性

Discription

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively.

Targets

Target	Value

产品信息

目录号	A19588
分子式	C54H68ClN11O9S2
分子量	1114.77
CAS号	2222354-29-0
SMILES	CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C(COCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@H](C8CCCCC8)NC([C@H](C)NC)=O)=O)CCC7)=N6)=O)=CC=C5)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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