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SNS-314 Mesylate是Aurora A，Aurora B和Aurora C的有效和选择性抑制剂，IC50分别为9 nM，31 nM和3 nM。 它对Trk A/B，Flt4，Fms，Axl，c-Raf和DDR2的效力较低。 阶段1。
靶点信息
| Aurora C | Aurora A | Aurora B | ||
| 3 nM | 9 nM | 31 nM |
| In vitro | DMSO | Warmed: 80 mg/mL (151.79 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 1 mg/mL (1.89 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.98 mL | 94.88 mL | 189.75 mL |
| 0.5 mM | 3.8 mL | 18.98 mL | 37.95 mL |
| 1 mM | 1.9 mL | 9.49 mL | 18.98 mL |
| 5 mM | 0.38 mL | 1.9 mL | 3.8 mL |
*The above data is based on the productmolecular weight 527.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10851 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 527.0 |
| Formula | C18H15ClN6OS2.CH4O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1057249-41-8 |
| Synonyms | SNS314 |
| SMILES | CS(=O)(=O)O.C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4 |
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