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Splitomicin是一种选择性的NAD(+)-依赖性组蛋白脱乙酰基酶Sir2p抑制剂，IC50为60 uM，在基于细胞的测定中显示出更高的活性。
靶点信息
| Sir2p | ||||
| 60 μM |
| In vitro | DMSO | 37 mg/mL (186.66 mM) | |
| Water | Insoluble | ||
| Ethanol | 37 mg/mL (186.66 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 50.45 mL | 252.24 mL | 504.49 mL |
| 0.5 mM | 10.09 mL | 50.45 mL | 100.9 mL |
| 1 mM | 5.04 mL | 25.22 mL | 50.45 mL |
| 5 mM | 1.01 mL | 5.04 mL | 10.09 mL |
*The above data is based on the productmolecular weight 198.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14221 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 198.22 |
| Formula | C13H10O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | CAS: 5690-03-9 |
| SMILES | C1CC(=O)OC2=C1C3=CC=CC=C3C=C2 |
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