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Hedgehog antagonist
GDC-0449（Vismodegib）是一种新型、特异性的合成口服刺猬通路抑制剂，其IC50为3 nM，具有更高的效力。- Yichuan You, .et al. , J Hazard Mater, 2023, Oct 15:460:132489 PMID: 37688871
- Yan Guo, .et al. , Differentiation, 2023, May-Jun;131:82-88 PMID: 37178555
- Mucahit Varli, .et al. , Sci Rep, 2023, Feb 16;13(1):2811 PMID: 36797277
- Daniel Doheny, .et al. , Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154
- Yi Yang, .et al. , Molecules, 2018, Nov; 23(11): 2968 PMID: 30441806
- Olesen UH, .et al. , Lasers Surg Med, 2018, Aug 28 PMID: 30152536
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GLI antagonist
GANT61 是一种抑制剂，针对 GLI1 以及 GLI2 引发的转录，抑制 hedgehog 信号通路，IC50 为 5 微摩尔，显示出对其他途径的选择性，如 TNF 和 糖皮质激素受体 基因激活。- Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418
- Cheng Zhou, .et al. , Cell Death Dis, 2021, Mar 3;12(3):231 PMID: 33658491
- Hui Liang, .et al. , Sci Rep, 2017, 7: 40361 PMID: 28098170
