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STF 118804是一种高度特异性的NAMPT抑制剂，可在低纳摩尔范围内降低大多数具有高效能IC50值的B-ALL细胞系的活力，并提高高危急性淋巴细胞白血病原位异种移植模型的存活率。
靶点信息
| NAMPT | ||||
| In vitro | DMSO | 53 mg/mL (114.83 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.67 mL | 108.34 mL | 216.67 mL |
| 0.5 mM | 4.33 mL | 21.67 mL | 43.33 mL |
| 1 mM | 2.17 mL | 10.83 mL | 21.67 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.33 mL |
*The above data is based on the productmolecular weight 461.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14072 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 461.53 |
| Formula | C25H23N3O4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 894187-61-2 |
| Synonyms | STF118804, STF-118804 |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)CC2=C(OC(=N2)C3=CC=C(C=C3)C(=O)NCC4=CN=CC=C4)C |
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