Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3??34.2 ?M, 26.1??0.3 ?M, 0.43??0.03 ?M, and 2.5??0.4 ?M for PAD1, PAD2, PAD3, and PAD4, respectively.
Cell Research
Cell Line
Type
Value
Description
References
Cell Line
Type
Value
Description
References
A549
IC50
0.33 μg/mL
Cytotoxicity against Homo sapiens (human) A549 cells after 72 hr by MTT assay
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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