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SU-5402是有效且选择性的血管内皮生长因子受体(VEGFR)和成纤维细胞生长因子受体(FGFR)抑制剂(在VEGFR2, FGFR1, PDGFRβ和EGFR处IC50值分别为0.02、0.03、0.51和> 100μM)。
靶点信息
| VEGFR2 | FGFR1 | PDGFRβ | ||
| 20 nM | 30 nM | 510 nM |
| In vitro | DMSO | 54 mg/mL (182.23 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.75 mL | 168.74 mL | 337.47 mL |
| 0.5 mM | 6.75 mL | 33.75 mL | 67.49 mL |
| 1 mM | 3.37 mL | 16.87 mL | 33.75 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
*The above data is based on the productmolecular weight 296.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11558 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 296.32 |
| Formula | C17H16N2O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 215543-92-3 |
| Synonyms | SU5402, SU 5402 |
| SMILES | CC1=CNC(=C1CCC(=O)O)/C=C\2/C3=CC=CC=C3NC2=O |
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