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SU11274是一种Met酪氨酸激酶抑制剂。
Targets
| Target | Value |
|---|---|
| Met | IC50: 0.01μM |
| Flk1 | IC50: 1.25μM |
| RON | IC50: 4.0μM |
| FGFR1 | IC50: 8.5μM |
| CDK2 | IC50: >10μM |
| PDGFRβ | IC50: >20μM |
| EGFR | IC50: >100μM |
| In vitro (25°C) | DMSO | 83 mg/mL (146.1 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.6 mL | 88.01 mL | 176.03 mL |
| 0.5 mM | 3.52 mL | 17.6 mL | 35.21 mL |
| 1 mM | 1.76 mL | 8.8 mL | 17.6 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.52 mL |
*The above data is based on the productmolecular weight 568.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10869 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 568.1 |
| Formula | C28H30CIN5O4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 658084-23-2 |
| Synonyms | SU-11274, PKI-SU11274 |
| SMILES | CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)/C=C\3/C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O |
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