TAE684

Name: TAE684
SKU: A10662
Price: 315 CNY
Rating: 5 (3 reviews)

目录号: A10662

ALK 抑制剂

3 篇发表文献

TAE684 是一种 ALK 抑制剂，同时也是 LRRK2 激酶活性的强效抑制剂（对野生型 LRRK2 的 IC(50) 为 7.8nM，对 G2019S 突变体的 IC(50) 为 6.1nM）。

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Grouped product items
规格	价格	库存
2mg	¥315.00	现货
5mg	¥525.00	现货
10mg	¥805.00	现货
25mg	¥1,540.00	现货
50mg	¥2,205.00	现货
100mg	¥3,115.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用TAE684发表的3篇文献

Yue Guo, .et al. , Cell Biosci, 2022, Dec 30;12(1):210 PMID: 36585695

Li Li, .et al. , Leukemia Res, 2019, 78:12-20 PMID: 30660961

Li T, .et al. , Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190

生物活性

Discription

TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant).

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10662
分子式	C30H40ClN7O3S
分子量	614.2
CAS号	761439-42-3
SMILES	CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC
其他名称	NVP-TAE684
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	3 mg/mL (4.88 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol, pH 4	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.28 mL	81.41 mL	162.81 mL
0.5 mM	3.26 mL	16.28 mL	32.56 mL
1 mM	1.63 mL	8.14 mL	16.28 mL
5 mM	0.33 mL	1.63 mL	3.26 mL

Useful Calculator

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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