TAE684

Name: TAE684
SKU: A10662

目录号: A10662

ALK 抑制剂

Product Citations (2)

TAE684 Chemical Structure

CAS NO. 761439-42-3

TAE684是ALK的抑制剂，也是LRRK2激酶活性的有效抑制剂（针对野生型LRRK2的IC（50）为7.8nM，针对G2019S突变体的为6.1nM）。

库存：现货

规格	价格	数量
5 mg	￥ 560.00
10 mg	￥ 840.00
50 mg	￥ 2,240.00
100 mg	￥ 3,150.00

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生物活性

TAE684是ALK的抑制剂，也是LRRK2激酶活性的有效抑制剂（针对野生型LRRK2的IC（50）为7.8nM，针对G2019S突变体的为6.1nM）。

靶点信息

ALK (Cell-free assay)
3 nM

溶解度 *

In vitro (25°C)	DMSO	3 mg/mL (4.88 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol, pH 4	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.28 mL	81.41 mL	162.81 mL
0.5 mM	3.26 mL	16.28 mL	32.56 mL
1 mM	1.63 mL	8.14 mL	16.28 mL
5 mM	0.33 mL	1.63 mL	3.26 mL

*The above data is based on the productmolecular weight 614.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10662
作用机制	Inhibitor (抑制剂)
M. Wt	614.2
Formula	C30H40ClN7O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	761439-42-3
Synonyms	NVP-TAE684 , TAE-684
SMILES	CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC