TAK-632

Name: TAK-632
SKU: A13323
Price: 210 CNY
Rating: 5 (1 reviews)

目录号: A13323

pan-RAF 抑制剂

1 篇发表文献

TAK-632 是一种强效的全 RAF 抑制剂，在体外活性良好（BRAF(V600E) IC50，2.4 nM；BRAF(wt)，8.3 nM；CRAF，1.4 nM；pMEK (A375) IC50，12 nM；pMEK (HMVII) IC50，49 nM；V/B 比率。

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Grouped product items
规格	价格	库存
5mg	¥210.00	现货
10mg	¥210.00	现货
25mg	¥420.00	现货
50mg	¥770.00	现货
100mg	¥1,505.00	现货
200mg	¥1,960.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用TAK-632发表的1篇文献

Yosi Shamay, .et al. , Nat Mater, 2018, Apr; 17(4): 361-368 PMID: 29403054

生物活性

Discription

TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A13323
分子式	C27H18F4N4O3S
分子量	554.51
CAS号	1228591-30-7
SMILES	C1CC1C(=O)NC2=NC3=C(S2)C(=C(C=C3)OC4=CC(=C(C=C4)F)NC(=O)CC5=CC(=CC=C5)C(F)(F)F)C#N
其他名称	TAK 632; TAK632
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	99 mg/mL (178.53 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (3.6 mM)
In vivo	2% DMSO+98% PEG 300	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.03 mL	90.17 mL	180.34 mL
0.5 mM	3.61 mL	18.03 mL	36.07 mL
1 mM	1.8 mL	9.02 mL	18.03 mL
5 mM	0.36 mL	1.8 mL	3.61 mL

Useful Calculator

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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