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TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.04 mL | 145.18 mL | 290.37 mL |
| 0.5 mM | 5.81 mL | 29.04 mL | 58.07 mL |
| 1 mM | 2.9 mL | 14.52 mL | 29.04 mL |
| 5 mM | 0.58 mL | 2.9 mL | 5.81 mL |
*The above data is based on the productmolecular weight 344.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20450 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 344.39 |
| Formula | C17H21FN6O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1312691-33-0 |
| Synonyms | TAK659, TAK 659 |
| SMILES | FC1=C(N[C@@H]2CCCC[C@@H]2N)N=C(C3=CN(C)N=C3)C4=C1CNC4=O |
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