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TAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.72 mL | 83.6 mL | 167.21 mL |
| 0.5 mM | 3.34 mL | 16.72 mL | 33.44 mL |
| 1 mM | 1.67 mL | 8.36 mL | 16.72 mL |
| 5 mM | 0.33 mL | 1.67 mL | 3.34 mL |
*The above data is based on the productmolecular weight 598.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21703 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 598.06 |
| Formula | C27H35ClF3N7O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1137868-96-2 |
| Synonyms | TAK 960, TAK960 |
| SMILES | CN1CCC(CC1)NC(=O)C2=CC(=C(C=C2F)NC3=NC=C4C(=N3)N(CC(C(=O)N4C)(F)F)C5CCCC5)OC.Cl |
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