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TAS-116 is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (Kis of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94. TAS-116 demonstrates less ocular toxicity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22 mL | 110 mL | 220.01 mL |
| 0.5 mM | 4.4 mL | 22 mL | 44 mL |
| 1 mM | 2.2 mL | 11 mL | 22 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.4 mL |
*The above data is based on the productmolecular weight 454.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20987 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 454.53 |
| Formula | C25H26N8O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1260533-36-5 |
| Synonyms | TAS116, TAS 116 |
| SMILES | O=C(N)C1=CC=C(N2N=C(C(C)C)C3=C(N4C=C(C5=CN(C)N=C5)N=C4)C=CN=C32)C(CC)=C1 |
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