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TC-A-2317 HCl是一种有效的Aurora激酶A抑制剂（Ki = 1.2 nM，而抑制Aurora激酶B则为101 nM）。选择性超过60种其他激酶（IC50值> 1000 nM）。表现出良好的细胞通透性和抗肿瘤活性。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.45 mL | 127.25 mL | 254.5 mL |
| 0.5 mM | 5.09 mL | 25.45 mL | 50.9 mL |
| 1 mM | 2.54 mL | 12.72 mL | 25.45 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.09 mL |
*The above data is based on the productmolecular weight 392.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13567 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 392.93 |
| Formula | C19H28N6O.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1245907-03-2 |
| Synonyms | TCA2317 |
| SMILES | CC(CCCC(C)(C)O)NC1=NC(NC2=NNC(C)=C2)=CC(C)=C1[N+]#[C-].Cl |
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