TCS ERK 11e (VX-11e)

Name: TCS ERK 11e (VX-11e)
SKU: A12505
Price: 315 CNY
Rating: 5 (1 reviews)

目录号: A12505

ERK2 抑制剂

1 篇发表文献

TCS ERK 11e (VX-11e) 是一种强效且选择性的细胞外信号相关激酶2（ERK2）抑制剂（Ki值分别为ERK2 <2 nM，GSK-3 395 nM，奥罗拉激酶A 540 nM和Cdk2 852 nM）。强效阻断HT29细胞的增殖（IC50 = 48 nM）。

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Grouped product items
规格	价格	库存
2mg	¥315.00	现货
5mg	¥560.00	现货
10mg	¥805.00	现货
25mg	¥1,505.00	现货
50mg	¥2,485.00	现货
100mg	¥3,955.00	现货
*10mM 1mL in DMSO**	¥630.00	现货
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Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用TCS ERK 11e (VX-11e)发表的1篇文献

Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418

生物活性

Discription

TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM).

Targets

Target	Value

产品信息

目录号	A12505
分子式	C24H20Cl2FN5O2
分子量	500.35
CAS号	896720-20-0
SMILES	CC1=CN=C(N=C1C2=CNC(=C2)C(=O)N[C@H](CO)C3=CC(=CC=C3)Cl)NC4=C(C=C(C=C4)F)Cl
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	94 mg/mL (187.87 mM)
	Water	Insoluble
	Ethanol	15 mg/mL (29.97 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.99 mL	99.93 mL	199.86 mL
0.5 mM	4 mL	19.99 mL	39.97 mL
1 mM	2 mL	9.99 mL	19.99 mL
5 mM	0.4 mL	2 mL	4 mL

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