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Tenovin-6是tenovin-1的类似物。Tenovin-6在体外抑制纯化的人SIRT1、SIRT2和SIRT3的蛋白脱乙酰酶活性，IC50值分别为21、10和67 uM。
靶点信息
| p53 | SIRT2 | SIRT1 | SIRT3 | |
| N/A | 10 μM | 21 μM | 67 μM |
| In vitro | DMSO | 87 mg/mL (191.36 mM) | |
| Water | Warmed: 87 mg/mL (191.36 mM) | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22 mL | 109.99 mL | 219.97 mL |
| 0.5 mM | 4.4 mL | 22 mL | 43.99 mL |
| 1 mM | 2.2 mL | 11 mL | 22 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.4 mL |
*The above data is based on the productmolecular weight 454.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12305 |
|---|---|
| 作用机制 | Activator (激活剂) |
| M. Wt | 454.6 |
| Formula | C25H34N4O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1011557-82-6 |
| Synonyms | Tenovin6, Tenovin 6 |
| SMILES | CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C |
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