TG101209

Name: TG101209
SKU: A11180

目录号: A11180

JAK2 抑制剂

TG101209 Chemical Structure

CAS NO. 936091-14-4

TG101209是一种新型的JAK2抑制剂，无细胞试验中IC50为6 nM，对Flt3和RET作用效果稍弱，IC50分别为25 nM和17 nM，作用于JAK2比作用于JAK3选择性高30倍左右，对JAK2V617F和MPLW515L/K突变型敏感。在多发性骨髓瘤中具有显着的体外活性，并且对CD45+骨髓瘤细胞显示出优先的细胞毒性。

库存：现货

规格	价格	数量
5 mg	￥ 490.00
10 mg	￥ 840.00
50 mg	￥ 1,890.00
100 mg	￥ 3,395.00
10mM * 1mL in DMSO	￥ 700.00

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产品详情

生物活性

靶点信息

JAK2 (Cell-free assay)	RET (Cell-free assay)	FLT3 (Cell-free assay)	JAK3 (Cell-free assay)
6 nM	17 nM	25 nM	169 nM

溶解度 *

In vitro (25°C)	DMSO	94 mg/mL (184.42 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	11 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.62 mL	98.1 mL	196.21 mL
0.5 mM	3.92 mL	19.62 mL	39.24 mL
1 mM	1.96 mL	9.81 mL	19.62 mL
5 mM	0.39 mL	1.96 mL	3.92 mL

*The above data is based on the productmolecular weight 509.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11180
作用机制	Inhibitor (抑制剂)
M. Wt	509.67
Formula	C26H35N7O2S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	936091-14-4
Synonyms	TG-101209
SMILES	CN1CCN(CC1)C2=CC=C(C=C2)NC3N=C(NC4=CC(=CC=C4)S(=O)(=O)NC(C)(C)C)C(C)=CN=3