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ROCK inhibitor
Fasudil HCl 是一种环核苷酸依赖性蛋白激酶抑制剂和Rho相关激酶抑制剂（IC50 = 10.7 μM）。- Jiwan Choi, .et al. , Stem Cell Res Ther, 2024, Jul 29;15(1):229 PMID: 39075621
- Patrick D Lyden, .et al. , Sci Transl Med, 2023, Sep 20;15(714):eadg8656 PMID: 37729432
- Seongjun So, .et al. , Int J Mol Sci, 2022, Dec 31;24(1):701 PMID: 36614165
- Chengyu Xiang, .et al. , J Cardiovasc Transl Res, 2022, May 12 PMID: 35551627
- Yeonmi Lee, .et al. , Commun Biol, 2022, Jan 25;5(1):95 PMID: 35079104
- Jiwan Choi, .et al. , Stem Cell Res Ther, 2021, Nov 12;12(1):569
- Jee Myung Yang, .et al. , Exp Mol Med, 2021, Apr;53(4):631-642 PMID: 33828232
- Jooyoung Lee, .et al. , Cells, 2020, Jun; 9(6): 1521 PMID: 32580448
- Kumar M, .et al. , Behav Brain Res, 2018, Oct 1;351:4-16 PMID: 29807069
- Wei J, .et al. , Shock, 2018, Dec;50(6):706-713 PMID: 29283979
- Hofni A, .et al. , Naunyn Schmiedebergs Arch Pharmacol, 2017, Aug;390(8):801-811 PMID: 28493050
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ROCK Inhibitor
GSK429286A 是一种细胞渗透性、选择性的小分子抑制剂，专门针对 Rho-associated, coiled-coil containing protein kinase (ROCK)。 -
ROCK Inhibitor
Y-27632 是一种 Rho-Associated Coil Kinase (ROCK) 抑制剂，能够提高人类胚胎干细胞（hESCs）的克隆效率。- Peilin Li, .et al. , Ecotoxicol Environ Saf, 2024, Dec:288:117330 PMID: 39571255
- Takaaki Fujimura, .et al. , NPJ Precis Oncol, 2024, Nov 17;8(1):264 PMID: 39551860
- Ayumi Horikawa, .et al. , In Vitro Cell Dev Biol Anim, 2024, Nov 15 PMID: 39546193
- Giovanni Tosi, .et al. , Nat Commun, 2024, Sep 18;15(1):8214 PMID: 39294175
- Christina Zarouchlioti, .et al. , EBioMedicine, 2024, Oct:108:105328 PMID: 39278108
- Kyunghyun Park, .et al. , Advanced Therapeutics, 2024, 7(6)
- Maude Hamilton, .et al. , Biol Open, 2024, Jan 15; 13(1): bio059919 PMID: 38252116
- Oliver Podmanicky, .et al. , Hum Mol Genet, 2024, Mar 1; 33(5): 435-447 PMID: 37975900
- Masayuki Fukumoto, .et al. , PLoS One, 2024, Dec 5;19(12):e0313312 PMID: 39636897
- Johannes Robert Fleischer, .et al. , Mol Cancer, 2023, Jan 24;22(1):17 PMID: 36691028
- Vignesh Jayarajan, .et al. , Cells, 2023, Jan 17;12(3):346 PMID: 36766688
- Giulia Bastianello, .et al. , Cell Rep, 2023, Dec 26;42(12):113555 PMID: 38088930
- Charlotte Phelps, .et al. , Sci Rep, 2023, Oct 23;13(1):18062 PMID: 37872186
- Mathilde Meyenberg, .et al. , Sci Rep, 2023, Aug 26;13(1):13964 PMID: 37633982
- Yu-Ting Wu, .et al. , J Biomed Sci, 2023, Aug 21;30(1):70 PMID: 37605213
- Heming Ning, .et al. , In Vitro Cell Dev Biol Anim, 2023, Jun;59(6):410-419 PMID: 37405627
- Eric Lian, .et al. , STAR Protoc, 2023, May 22;4(2):102314 PMID: 37220001
- Stephanie T Pohl, .et al. , Methods Mol Biol, 2023, 2584:371-387 PMID: 36495461
- Charlotte Phelps, .et al. , Am J Physiol Cell Physiol, 2023, Mar 1;324(3):C787-C797 PMID: 36689673
- Shunsuke Murakami, .et al. , Regen Ther, 2022, Nov 25;21:574-583 PMID: 36475025
- Sergio Pedraza-Arevalo, .et al. , STAR Protoc, 2022, Aug 30;3(3):101656 PMID: 36092820
- Ji-Hyun Lee, .et al. , Cell Stem Cell, 2022, May 5; 29(5): 826-839 PMID: 35523142
- Adam Pietrobon, .et al. , Cell Rep, 2022, Jul 5;40(1):111048 PMID: 35793620
- Sarkawt Hamad, .et al. , Stem Cell Res Ther, 2022, Jun 11;13(1):251 PMID: 35690874
- Stasia Krishtul, .et al. , Polym Adv Technol, 2022, 33( 11): 3842-3852
- Peter T Ruane, .et al. , Hum Reprod, 2022, Apr 1;37(4):777-792 PMID: 35079788
- Takayuki Miyoshi, .et al. , J Gastroenterol, 2022, Jun;57(6):441-452 PMID: 35294680
- Ana-Maria Cujba, .et al. , Cell Rep, 2022, Mar 1;38(9):110425 PMID: 35235779
- Dan Zhao, .et al. , Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
- Antigoni Gogolou, .et al. , Curr Protoc, 2021, Jun;1(6):e137 PMID: 34102038
- Tiago De Oliveira, .et al. , Cancers (Basel), 2021, Mar 2;S2451-9456(21)00095-7 PMID: 33671096
- Denise Muller, .et al. , BMC Med, 2021, Nov 16;19(1):300 PMID: 34781947
- Ayumi Horikawa, .et al. , PloS one, 2021, Jul 12;16(7):e0254373 PMID: 34252142
- Hayato Mizuta, .et al. , Nat Commun, 2021, Feb 24;12(1):1261 PMID: 33627640
- Scott Bell, .et al. , Stem Cell Reports, 2021, Jul 13;16(7):1749-1762 PMID: 34214487
- Shenyang Li, .et al. , J Cell Mol Med, 2020, Dec 20;25(2):1207-1220 PMID: 33342057
- Takao FUCHIGAMI, .et al. , J Appl Oral Sci, 2020, 28: e20190558 PMID: 32348439
- Jing-Yu Lin, .et al. , Cell Discov, 2020, 6: 20 PMID: 32284878
- Yu Huang, .et al. , Stem Cells Int, 2019, 2019: 3975689 PMID: 31565060
- XinYan, .et al. , Stem Cell Res, 2019, May 17 PMID: 31141763
- Daniela F. Duarte Campos, .et al. , J Biomed Mater Res A, 2019, April 22 PMID: 31012205
- Scott Bell, .et al. , Am J Hum Genet, 2019, May 2;104(5):815-834 PMID: 31031012
- Ooi J, .et al. , Cell Rep, 2019, Feb 26;26(9):2494-2508 PMID: 30811996
- Scott Bell, .et al. , Stem Cell Reports, 2018, Jul 10; 11(1):183-196 PMID: 29937144
- Christina Zarouchlioti, .et al. , Am J Hum Genet, 2018, Apr 5; 102(4): 528-539 PMID: 29526280
- Ai Takemoto, .et al. , Sci Rep, 2017, 7: 42186 PMID: 28176852
- Scott Bell, .et al. , Stem Cells Transl Med, 2017, Mar; 6(3): 886-896 PMID: 28170165
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ROCK inhibitor
GSK 269962 是一种强效的 Rho 激酶（ROCK）抑制剂（对重组人类 ROCK1 和 ROCK2 的 IC50 值分别为 1.6 和 4 nM）。- Praneeth Siripurapu, .et al. , J Biol Chem, 2017, Oct 20; 292(42): 17482-17495 PMID: 28864771
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ROCK inhibitor
SR 3677 二盐酸盐是一种强效且选择性的Rho激酶抑制剂（IC50值分别为ROCK-II的3 nM和ROCK-I的56 nM）。 -
ROCK inhibitor
Glycyl-H 1152 2HCl 是一种选择性且高效的 ROCK 抑制剂（IC50 值分别为 0.0118、2.35、2.57、3.26、>10 和 >10 uM，针对 ROCKII、Aurora A、CAMKII、PKG、PKA 和 PKC）。 -
ROCK inhibitor
H-1152 二盐酸盐，一种异喹啉磺胺衍生物，是一种更具特异性、更强效且可渗透细胞膜的Rho激酶抑制剂，其Ki值为1.6 nM，但对其他丝氨酸/苏氨酸激酶的抑制作用较弱。 -
ROCK inhibitor
Hydroxyfasudil hydrochloride，Fasudil的代谢物，是一种强效的Rho-激酶抑制剂和血管扩张剂。 -
ROCK inhibitor
ROCK inhibitor 是一种高效的抑制剂，能够抑制人类的 ROCK-1 和 ROCK-2 异构酶，其 IC50 值分别为 0.6 nM 和 1.1 nM。- Delia Talpan, .et al. , Int J Mol Sci, 2023, Jan 11;24(2):1461 PMID: 36674976
- Nina Seidelmann, .et al. , J Cell Mol Med, 2021, Oct;25(20):9647-9659 PMID: 34486211
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ROCK2 Inhibitor
SLx-2119 是一种小分子，并且是 ROCK2 的选择性抑制剂，其 IC50 为 105 nM；对 ROCK1 的选择性超过 200 倍（IC50 = 24 uM）。 -
ROCK inhibitor
Ripasudil (K-115) 是一种强效的 ROCK 抑制剂，其 IC50 分别为 51 nM 和 19 nM，针对 ROCK1 和 ROCK2，用于治疗青光眼和眼压过高。- Tilahun Ayane Debele, .et al. , Transl Vis Sci Technol, 2023, Dec; 12(12): 4 PMID: 38051267
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ROCK1/ROCK2 inhibitor
ROCK inhibitor-2 是一种选择性的双重 ROCK1 和 ROCK2 抑制剂，其 IC50 分别为 17 nM 和 2 nM。 -
ROCK-I/ROCK-II inhibitor
Y-27632 是一种针对 ROCK-I 和 ROCK-II 的 ATP 竞争性抑制剂，其对 ROCK-I 和 ROCK-II 的 Ki 分别为 220 nM 和 300 nM。- Sara B Linker, .et al. , Curr Biol, 2022, Nov 21;32(22):4797-4807 PMID: 36228612
- Renata Santos, .et al. , STAR Protoc, 2022, Mar 17;3(2):101261 PMID: 35313707
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PKs inhibitor
HA-100 是一种添加了哌嗪磺酰基的异喹啉化合物，它作为蛋白激酶（PKs）的抑制剂，包括 PKA、PKC 和 PKG（IC50 分别为 8、12 和 4 微摩尔）。 -
MRTF pathway inhibitor
CCG-222740 是一种口服活性且选择性的 Rho/心肌相关转录因子 (MRTF) 通路抑制剂。CCG-222740 也是一种强效的 α-平滑肌肌动蛋白 蛋白表达抑制剂。
