你的浏览器似乎禁用了 JavaScript。
您必须在浏览器中启用JavaScript才能使用本网站的功能。

微信关注
申请试用装

主页 /
TGF-β / Smad

TGF-β / Smad

Quick View
SR 3677 dihydrochloride

Catalog No. A12674
Quick View

添加到收藏
ROCK 抑制剂

SR 3677 dihydrochloride是一种有效的选择性Rho激酶抑制剂（ROCK-II和ROCK-I的IC50值分别为3和56 nM）。了解更多

Bulk Inquiry
Quick View
Hydroxyfasudil hydrochloride

Catalog No. A15119
Quick View

添加到收藏
ROCK 抑制剂

Hydroxyfasudil hydrochloride是法舒地尔的代谢产物，是一种有效的Rho激酶抑制剂和血管舒张剂。了解更多

Bulk Inquiry
Quick View
Hydroxyfasudil

Catalog No. A15118
Quick View

添加到收藏
ROCK 抑制剂

Hydroxyfasudil是法舒地尔的代谢产物，是有效的Rho激酶抑制剂和血管舒张剂。了解更多

Bulk Inquiry
Quick View
ROCK inhibitor

Catalog No. A15225
Quick View

添加到收藏
ROCK 抑制剂

ROCK inhibitor是人类ROCK-1和ROCK-2同工酶的高效抑制剂，IC50值分别为0.6和1.1 nM。了解更多

Product Citations (1)

Bulk Inquiry
- Nina Seidelmann, .et al. Human platelet lysate as a replacement for fetal bovine serum in human corneal stromal keratocyte and fibroblast culture, J Cell Mol Med, 2021, Oct;25(20):9647-9659 PMID: 34486211
Quick View
ROCK inhibitor-1

Catalog No. A15226
Quick View

添加到收藏
ROCK 抑制剂

N/A 了解更多

Bulk Inquiry
Quick View
LX7101

Catalog No. A16211
Quick View

添加到收藏
LIMK2 抑制剂

LX7101是基于吡咯并嘧啶的局部递送的LIM域激酶2（LIMK2）抑制剂，LIM域激酶2是与眼内压调节相关的激酶。了解更多

Bulk Inquiry
Quick View
Ripasudil

Catalog No. A15888
Quick View

添加到收藏
ROCK inhibitor

Ripasudil (K-115) is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension. 了解更多

Bulk Inquiry
Quick View
SAR407899 HCl

Catalog No. A15921
Quick View

添加到收藏
ROCK 抑制剂

SAR407899是一种有效且选择性的Rho激酶抑制剂，具有良好的抗高血压活性。了解更多

Bulk Inquiry
Quick View
SLx-2119 (KD025)

Catalog No. A15239
Quick View

添加到收藏
ROCK2 抑制剂

SLx-2119 (KD025)是ROCK2的小分子和选择性抑制剂，IC50为105 nM。在ROCK1上的选择性> 200倍（IC50 = 24 uM）。了解更多

Bulk Inquiry
Quick View
Glycyl-H 1152 2HCl

Catalog No. A13659
Quick View

添加到收藏
ROCK 抑制剂

Glycyl-H 1152 2HCl是一种选择性有效的ROCK抑制剂（ROCKII，Aurora A，CAMKII，PKG，PKA和PKC的IC50值分别为0.0118、2.35、2.57、3.26，> 10和> 10 uM。）了解更多

Bulk Inquiry
Quick View
H-1152 dihydrochloride

Catalog No. A15102
Quick View

添加到收藏
ROCK 抑制剂

H-1152 dihydrochloride是一种异喹啉磺酰胺衍生物，是Rho激酶的一种更特异，更强且可透过膜的抑制剂，Ki值为1.6 nM，但对其他丝氨酸/苏氨酸激酶的抑制作用较弱。了解更多

Bulk Inquiry
Quick View
H-1152

Catalog No. A15101
Quick View

添加到收藏
ROCK 抑制剂

H-1152是一种异喹啉磺酰胺衍生物，是Rho激酶的一种更特异，更强且可透过膜的抑制剂，Ki值为1.6 nM，但对其他丝氨酸/苏氨酸激酶的抑制作用较差。了解更多

Bulk Inquiry Free Sample
Quick View
chroman 1

Catalog No. A15045
Quick View

添加到收藏
ROCK 抑制剂

Chroman 1 是一种高效且选择性的ROCK II抑制剂。了解更多

Bulk Inquiry
Quick View
RKI-1447

Catalog No. A13067
Quick View

添加到收藏
ROCK1/ROCK2 抑制剂

RKI-1447是Rho相关ROCK激酶的有效抑制剂，在乳腺癌中具有抗侵袭和抗肿瘤活性。了解更多

Bulk Inquiry Free Sample
Quick View
Y-33075

Catalog No. A11610
Quick View

添加到收藏
ROCK 抑制剂

Y-33075是ROCK（Rho相关的卷曲螺旋形成蛋白激酶）抑制剂。了解更多

Bulk Inquiry
Quick View
HA-1077 dihydrochloride

Catalog No. A13785
Quick View

添加到收藏
ROCK 抑制剂

HA-1077 dihydrochloride通过充当细胞内Ca2+拮抗剂来抑制血管平滑肌收缩。了解更多

Bulk Inquiry
Quick View
Fasudil HCl (HA-1077)

Catalog No. A10381
Quick View

添加到收藏
ROCK 抑制剂

Fasudil HCl (HA-1077)是一种环状核苷酸依赖性蛋白激酶抑制剂和Rho相关激酶抑制剂（IC50 = 10.7μM）。了解更多

Product Citations (8)

Bulk Inquiry Free Sample
- Chengyu Xiang, .et al. Fasudil Ameliorates Osteoporosis Following Myocardial Infarction by Regulating Cardiac Calcitonin Secretion, J Cardiovasc Transl Res, 2022, May 12 PMID: 35551627
- Yeonmi Lee, .et al. Haploidy in somatic cells is induced by mature oocytes in mice, Commun Biol, 2022, Jan 25;5(1):95 PMID: 35079104
- Jiwan Choi, .et al. Efficient hepatic differentiation and regeneration potential under xeno-free conditions using mass-producible amnion-derived mesenchymal stem cells, Stem Cell Res Ther, 2021, Nov 12;12(1):569
- Jee Myung Yang, .et al. Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats, Exp Mol Med, 2021, Apr;53(4):631-642 PMID: 33828232
- Jooyoung Lee, .et al. Hepatogenic Potential and Liver Regeneration Effect of Human Liver-derived Mesenchymal-Like Stem Cells, Cells, 2020, Jun; 9(6): 1521 PMID: 32580448
- Kumar M, .et al. Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NFκB, Behav Brain Res, 2018, Oct 1;351:4-16 PMID: 29807069
- Wei J, .et al. Inhibition of RHO Kinase by Fasudil Attenuates Ischemic Lung Injury After Cardiac Arrest in Rats, Shock, 2018, Dec;50(6):706-713 PMID: 29283979
- Hofni A, .et al. Fasudil ameliorates endothelial dysfunction in streptozotocin-induced diabetic rats: a possible role of Rho kinase, Naunyn Schmiedebergs Arch Pharmacol, 2017, Aug;390(8):801-811 PMID: 28493050
Quick View
GSK 269962

Catalog No. A12348
Quick View

添加到收藏
ROCK 抑制剂

GSK 269962是一种强效Rho激酶(ROCK)抑制剂(重组人ROCK1和ROCK2的IC50值分别为1.6和4 nM)。了解更多

Product Citations (1)

Bulk Inquiry
- Praneeth Siripurapu, .et al. Two independent but synchronized Gβγ subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration, J Biol Chem, 2017, Oct 20; 292(42): 17482-17495 PMID: 28864771
Quick View
GSK429286A

Catalog No. A10441
Quick View

添加到收藏
ROCK 抑制剂

GSK429286A是含有蛋白激酶(ROCK)的Rho相关卷曲螺旋的细胞渗透性选择性小分子抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
Thiazovivin

Catalog No. A10928
Quick View

添加到收藏
ROCK 抑制剂

Thiazovivin是一种Rho相关激酶（ROCK）的选择性抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
RKI-1313

Catalog No. A10899
Quick View

添加到收藏
ROCK 抑制剂

RKI-1313是RKI-1447的阴性对照，RKI-1447是Rho相关的ROCK激酶的有效抑制剂，在乳腺癌中具有抗侵袭和抗肿瘤活性。了解更多

Bulk Inquiry
Quick View
BMS-5

Catalog No. A12839
Quick View

添加到收藏
LIMK 抑制剂

BMS-5是一种有效的LIMK抑制剂，对LIMK1和LIMK2的IC50分别为7 nM和8 nM。了解更多

Bulk Inquiry
Quick View
BDP5290

Catalog No. A16966
Quick View

添加到收藏
ROCK and MRCK 抑制剂

BDP5290是ROCK和MRCK的有效抑制剂，对ROCK1，ROCK2，MRCKα和MRCKβ的IC50分别为5 nM，50 nM，10 nM和100 nM。了解更多

Bulk Inquiry
Quick View
R-10015

Catalog No. A18806
Quick View

添加到收藏
LIMK inhibitor

R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1. 了解更多

Bulk Inquiry
Quick View
ROCK inhibitor-2

Catalog No. A18912
Quick View

添加到收藏
ROCK1/ROCK2 inhibitor

ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively. 了解更多

Bulk Inquiry
Quick View
T56-LIMKi

Catalog No. A12266
Quick View

添加到收藏
LIMK2 inhibitor

T56-LIMKi is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM. 了解更多

Bulk Inquiry
Quick View
Y-33075 dihydrochloride

Catalog No. A11611
Quick View

添加到收藏
ROCK inhibitor

Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM. 了解更多

Bulk Inquiry
Quick View
Y-27632

Catalog No. A21448
Quick View

添加到收藏
ROCK-I/ROCK-II inhibitor

Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively. 了解更多

Product Citations (1)

Bulk Inquiry
- Renata Santos, .et al. Generation of inflammation-responsive astrocytes from glial progenitors derived from human pluripotent stem cells, STAR Protoc, 2022, Mar 17;3(2):101261 PMID: 35313707
Quick View
Fasudil

Catalog No. A21628
Quick View

添加到收藏
ROCK inhibitor

Fasudil (HA-1077; AT877), is a nonspecific ROCK inhibitor and also has inhibitory effect on protein kinases. 了解更多

Bulk Inquiry
Quick View
BMS-3

Catalog No. A20999
Quick View

添加到收藏
LIMK inhibitor

BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively. 了解更多

Bulk Inquiry
Quick View
Y-27632 2HCl

Catalog No. A11001
Quick View

添加到收藏
ROCK 抑制剂

Y-27632是一种Rho相关的线圈激酶（ROCK）抑制剂，可提高人类胚胎干细胞（hESCs）的克隆效率。比对其他激酶包括PKC，cAMP依赖性蛋白激酶，MLCK和PAK的作用强200多倍。了解更多

Product Citations (27)

Bulk Inquiry Free Sample
- Sergio Pedraza-Arevalo, .et al. Differentiation of beta-like cells from human induced pluripotent stem cell-derived pancreatic progenitor organoids, STAR Protoc, 2022, Aug 30;3(3):101656 PMID: 36092820
- Ji-Hyun Lee, .et al. p57Kip2 imposes the reserve stem cell state of gastric chief cells, Cell Stem Cell, 2022, May 5; 29(5): 826-839 PMID: 35523142
- Adam Pietrobon, .et al. Renal organoid modeling of tuberous sclerosis complex reveals lesion features arise from diverse developmental processes, Cell Rep, 2022, Jul 5;40(1):111048 PMID: 35793620
- Sarkawt Hamad, .et al. High-efficient serum-free differentiation of endothelial cells from human iPS cells, Stem Cell Res Ther, 2022, Jun 11;13(1):251 PMID: 35690874
- Stasia Krishtul, .et al. Development of a bioactive microencapsulation platform incorporating decellularized extracellular matrix to entrap human induced pluripotent stem cells for versatile biomedical applications, Polym Adv Technol, 2022, 33( 11): 3842-3852
- Peter T Ruane, .et al. Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation, Hum Reprod, 2022, Apr 1;37(4):777-792 PMID: 35079788
- Takayuki Miyoshi, .et al. Successful induction of human chemically induced liver progenitors with small molecules from damaged liver, J Gastroenterol, 2022, Jun;57(6):441-452 PMID: 35294680
- Ana-Maria Cujba, .et al. An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function, Cell Rep, 2022, Mar 1;38(9):110425 PMID: 35235779
- Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
- Antigoni Gogolou, .et al. Generating Enteric Nervous System Progenitors from Human Pluripotent Stem Cells, Curr Protoc, 2021, Jun;1(6):e137 PMID: 34102038
- Tiago De Oliveira, .et al. Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo, Cancers (Basel), 2021, Mar 2;S2451-9456(21)00095-7 PMID: 33671096
- Denise Muller, .et al. Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas, BMC Med, 2021, Nov 16;19(1):300 PMID: 34781947
- Ayumi Horikawa, .et al. A simple method of hiPSCs differentiation into insulin-producing cells is improved with vitamin C and RepSox, PloS one, 2021, Jul 12;16(7):e0254373 PMID: 34252142
- Hayato Mizuta, .et al. Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer, Nat Commun, 2021, Feb 24;12(1):1261 PMID: 33627640
- Scott Bell, .et al. Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells, Stem Cell Reports, 2021, Jul 13;16(7):1749-1762 PMID: 34214487
- Shenyang Li, .et al. Effect of porcine corneal stromal extract on keratocytes from SMILE-derived lenticules, J Cell Mol Med, 2020, Dec 20;25(2):1207-1220 PMID: 33342057
- Takao FUCHIGAMI, .et al. Ameloblastoma cell lines derived from different subtypes demonstrate distinct developmental patterns in a novel animal experimental model, J Appl Oral Sci, 2020, 28: e20190558 PMID: 32348439
- Jing-Yu Lin, .et al. In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals, Cell Discov, 2020, 6: 20 PMID: 32284878
- Yu Huang, .et al. Development of Bifunctional Three-Dimensional Cysts from Chemically Induced Liver Progenitors, Stem Cells Int, 2019, 2019: 3975689 PMID: 31565060
- XinYan, .et al. Establishment of CSUASOi001-A, a non-integrated induced pluripotent stem cell line from urine-derived cells of a Chinese patient carrying RS1 gene mutation, Stem Cell Res, 2019, May 17 PMID: 31141763
- Daniela F. Duarte Campos, .et al. Corneal bioprinting utilizing collagen?\based bioinks and primary human keratocytes, J Biomed Mater Res A, 2019, April 22 PMID: 31012205
- Scott Bell, .et al. Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons, Am J Hum Genet, 2019, May 2;104(5):815-834 PMID: 31031012
- Ooi J, .et al. Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects, Cell Rep, 2019, Feb 26;26(9):2494-2508 PMID: 30811996
- Scott Bell, .et al. Disruption of GRIN2B Impairs Differentiation in Human Neurons, Stem Cell Reports, 2018, Jul 10; 11(1):183-196 PMID: 29937144
- Christina Zarouchlioti, .et al. Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity, Am J Hum Genet, 2018, Apr 5; 102(4): 528-539 PMID: 29526280
- Ai Takemoto, .et al. A critical role of platelet TGF-β release in podoplanin-mediated tumour invasion and metastasis, Sci Rep, 2017, 7: 42186 PMID: 28176852
- Scott Bell, .et al. A Rapid Pipeline to Model Rare Neurodevelopmental Disorders with Simultaneous CRISPR/Cas9 Gene Editing, Stem Cells Transl Med, 2017, Mar; 6(3): 886-896 PMID: 28170165
Quick View
A-674563

Catalog No. A11034
Quick View

添加到收藏
Akt 抑制剂

A-674563是一种B/Akt抑制剂，IC50为14 nM，并且还显示出对PKA和CDK2的抑制活性，IC50分别为16和46 nM。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- Kobayashi T, .et al. A-674563 increases chondrocyte marker expression in cultured chondrocytes by inhibiting Sox9 degradation, Biochem Biophys Res Commun, 2018, Jan 1;495(1):1468-1475 PMID: 29196261
- Lin Xu, .et al. Concurrent targeting Akt and sphingosine kinase 1 by A-674563 in acute myeloid leukemia cells, Biochem Biophys Res Commun, 2016, Apr 15;472(4):662-8 PMID: 26920060
- Zou Y, .et al. Pre-clinical assessment of A-674563 as an anti-melanoma agent, Biochem Biophys Res Commun, 2016, Aug 12;477(1):1-8 PMID: 26970307
Quick View
H 89 2HCl

Catalog No. A11935
Quick View

添加到收藏
PKA 抑制剂

H 89 dihydrochloride是一种可渗透细胞的，选择性的，可逆的，具有ATP竞争性的有效蛋白激酶抑制剂。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Guo Q, .et al. Antineuropathic pain actions of Wu-tou decoction resulted from the increase of neurotrophic factor and decrease of CCR5 expression in primary rat glial cells, Biomed Pharmacother, 2020, Mar;123:109812 PMID: 31945696
- Y Kaibori, .et al. EphA2 phosphorylation at Ser897 by the Cdk1/MEK/ERK/RSK pathway regulates M-phase progression via maintenance of cortical rigidity, the FASEB Journal, 2019, Jan 22:fj201801519RR PMID: 30668924
Quick View
AT13148

Catalog No. A12464
Quick View

添加到收藏
multi-AGC kinase 抑制剂

AT13148是一种新型多AGC激酶抑制剂，具有强大的药效和抗肿瘤活性，与其他AKT抑制剂相比，具有独特的作用机理。了解更多

Bulk Inquiry
Quick View
AT7867 2HCl

Catalog No. A15006
Quick View

添加到收藏
Akt 抑制剂

AT7867 dihydrochloride是一种有效的ATP竞争性Akt1/2/3和p70S6K/PKA抑制剂，IC50分别为32 nM/17 nM/47 nM和85 nM/20 nM，在AGC激酶家族之外几乎没有活性。了解更多

Bulk Inquiry
Quick View
KT 5720

Catalog No. A16016
Quick View

添加到收藏
PKA 抑制剂

KT5720 是一种能透过细胞的、有效的、特异性的、可逆的、ATP 竞争性的蛋白酶 K (PKA) 的抑制剂，其 Ki 值为 60 nM。了解更多

Bulk Inquiry
Quick View
PKI 14-22 amide, myristoylated

Catalog No. A16031
Quick View

添加到收藏
PKA 抑制剂

PKI 14-22 amide, myristoylated是有用的热稳定的cAMP依赖性蛋白激酶抑制剂。这通常用于体外研究细胞系统中的PKA。了解更多

Product Citations (1)

Bulk Inquiry
- Dao-Lai Zhang, .et al. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 PMID: 29393851
Quick View
cGMP Dependent Kinase Inhibitor Peptid

Catalog No. A16052
Quick View

添加到收藏
PKG/PKA 抑制剂

cGMP Dependent Kinase Inhibitor Peptid是一种特定的cGKI（环GMP依赖性蛋白激酶）抑制剂。数据表明，它不阻断完整组蛋白的环状GMP依赖性蛋白激酶磷酸化，已被用于研究恶性疟原虫。了解更多

Bulk Inquiry
Quick View
CCG215022

Catalog No. A16189
Quick View

添加到收藏
GRK2/5 抑制剂

CCG215022是有效的GRK2和GRK5抑制剂。CCG215022对GRK2和GRK5均表现出纳摩尔IC50值，对其他紧密相关的激酶（如GRK1和PKA）具有良好的选择性。了解更多

Bulk Inquiry
Quick View
A-3 Hydrochloride

Catalog No. A13584
Quick View

添加到收藏
PKA, PKG, Casein Kinase I and II 抑制剂

A-3 Hydrochloride是PKA（cAMP依赖性蛋白激酶，Ki =4.3μM）和cGMP依赖性蛋白激酶，Ki =3.8μM，PKC（蛋白激酶C，Ki =47μM），酪蛋白激酶I和II的抑制剂，和MLCK（肌球蛋白轻链激酶）（Ki =7.4μM）。了解更多

Bulk Inquiry
Quick View
PKA inhibitor fragment (6-22) amide

Catalog No. A14868
Quick View

添加到收藏
PKA 抑制剂

PKA inhibitor fragment (6-22) amide是一种合成肽，可作为蛋白激酶抑制剂。了解更多

Bulk Inquiry
Quick View
cAMPS-Rp, triethylammonium salt

Catalog No. A16028
Quick View

添加到收藏
reversible PKA 抑制剂

cAMPS-Rp,triethylammonium salt是PKA（蛋白激酶A）（Ki = 11 uM）的细胞渗透性和可逆抑制剂.Rp-cAMPS耐磷酸二酯酶水解，相对于ATP不具竞争力。了解更多

Bulk Inquiry
Quick View
LY317615 (Enzastaurin)

Catalog No. A10356
Quick View

添加到收藏
PKCβ 抑制剂

LY317615（Enzastaurin）是一种有效的，选择性的PKCβ抑制剂，具有抗增殖活性（IC50 =?6 nM）。了解更多

Bulk Inquiry Free Sample
Quick View
Daphnetin

Catalog No. A10286
Quick View

添加到收藏
EGFR, PKA,PKC 抑制剂

Daphnetin是一种香豆素类似物，可作为几种蛋白激酶的抑制剂。它在体外抑制EGFR激酶（IC50 = 7.67 ?M），PKA（IC50 = 9.33 ?M）和PKC（IC50 = 25 ?M）。蜂胶对EGFR激酶的抑制作用与ATP竞争，对肽底物没有竞争性。还可以用作有效的抗氧化剂和抗疟疾剂。了解更多

Bulk Inquiry Free Sample
Quick View
Quercetin (Sophoretin)

Catalog No. A10766
Quick View

添加到收藏
MAO-B 抑制剂

Quercetin (Sophoretin)抑制许多酶系统，包括酪氨酸蛋白激酶，磷脂酶A2，磷酸二酯酶，线粒体ATPase，PI 3-激酶和蛋白激酶C。了解更多

Bulk Inquiry Free Sample
Quick View
Chelerythrine Chloride

Catalog No. A10196
Quick View

添加到收藏
PKC 抑制剂

Chelerythrine Chloride是一种有效的，选择性的PKC拮抗剂， IC50为0.66 μM。影响PKC从细胞质到质膜的转运。显示可防止神经突生长。以浓度和时间表依赖性方式诱导凋亡。了解更多

Bulk Inquiry Free Sample
Quick View
Bryostatin 1

Catalog No. A10261
添加到收藏
PKC 抑制剂

Bryostatin 1是从海洋苔藓动物Bugula neritina分离的大内酯，可调节蛋白激酶C（PKC）活性。 Bryostain 1诱导了PKC的初始快速活化和自磷酸化，从而导致PKC酶向膜的移位。了解更多

Bulk Inquiry
Quick View
Sotrastaurin (AEB071)

Catalog No. A11554
Quick View

添加到收藏
PKC 抑制剂

Sotrastaurin是一种有效的 pan-PKC 抑制剂，作用于PKCθ，PKCβ，PKCα，PKCη，PKCδ 和PKCε，Ki 分别为 0.22 nM，0.64 nM，0.95 nM，1.8 nM，2.1 nM 和 3.2 nM。用于预防移植排斥反应和治疗牛皮癣。了解更多

Bulk Inquiry Free Sample
Quick View
Staurosporine

Catalog No. A10864
Quick View

添加到收藏
PKC 抑制剂

Staurosporine是一种天然产物，最初于1977年从Streptomyces staurosporeus细菌中分离出来。星形孢菌素的主要生物学活性是通过防止ATP与激酶的结合来抑制蛋白激酶。是一种有效的PKC抑制剂，在无细胞试验中作用于PKCα，PKCγ 和PKCη，IC50分别为2 nM，5 nM 和 4 nM，对PKCδ(20 nM)和PKCε(73 nM作用较弱，对PKCζ (1086 nM)的活性很低。同时对其他的激酶PKA, PKG, S6K, CaMKII, 等也显示抑制活性。了解更多

Product Citations (3)

Bulk Inquiry
- Lisa M Kim, .et al. Sustained Oncogenic Signaling in the Cytostatic State Enables Targeting of Nonproliferating Persistent Cancer Cells, Cancer Res, 2022, Sep 2;82(17):3045-3057 PMID: 35792658
- Jacobs CL, .et al. StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins, Nat Methods, 2018, Jul;15(7):523-526 PMID: 29967496
- Birte Plitzko, .et al. The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells, J Biol Chem, 2017, Dec 22; 292(51): 21102-21116 PMID: 29074620
Quick View
Go 6976

Catalog No. A12419
添加到收藏
PKC 抑制剂

Go6976是一种有效的PKC抑制剂，对PKC（大鼠脑），PKCα和PKCβ1的IC50分别为7.9 nM，2.3 nM和6.2 nM。也是JAK2和Flt3的有效抑制剂。了解更多

Bulk Inquiry

联系我们

Not your Region? View all Distributors

溶液配制计算器

分子量计算器

稀释计算器

摩尔浓度计算器

ADOOQ 产品质量保证

Guaranteed product quality, 365 days Unconditional Return & Replacement

We promise all products to perform as described.