TH588

Name: TH588
SKU: A15537
Price: 210 CNY
Rating: 5 (288 reviews)

目录号: A15537

MTH1 inhibitor

TH588 是首个属于 nudix hydrolase 家族的抑制剂，它能够强效且选择性地结合并抑制细胞中的 MTH1（IC50= 5 nM），

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规格	价格	库存
2mg	¥210.00	现货
5mg	¥350.00	现货
10mg	¥525.00	现货
25mg	¥840.00	现货
50mg	¥1,470.00	现货
100mg	¥2,835.00	现货
*10mM 1mL in DMSO**	¥385.00	现货
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Data Sheet

SDS

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生物活性

Discription

TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells,

Targets

Cell Research

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Cell Line	Type	Value	Description	References
A549	GI50	3.3 μM	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 5 days by Hoechst 33342 dye based cell counting analysis	[PMID: 26878898]
HeLa	GI50	3.8 μM	Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by resazurin dye based fluorescent assay	[PMID: 31077996]
MCF7	GI50	4 μM	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 7 days by Hoechst 33342 dye based cell counting analysis	[PMID: 26878898]
NCI-H358	GI50	2.3 μM	Antiproliferative activity against human NCI-H358 cells assessed as cell growth inhibition incubated for 5 days by Hoechst 33342 dye based cell counting analysis	[PMID: 26878898]
SW480	EC50	9.7 μM	Cytotoxicity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter glo assay	[PMID: 32184970]
U2OS	GI50	3 μM	Antiproliferative activity against human U2OS cells assessed as cell growth inhibition incubated for 5 days by Hoechst 33342 dye based cell counting analysis	[PMID: 26878898]
U2OS	EC50	5.6 μM	Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by celltiter glo assay	[PMID: 32184970]

Showing 1 to 7 of 7 entries

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产品信息

目录号	A15537
分子式	C13H12Cl2N4
分子量	295.17
CAS号	1609960-31-7
SMILES	C1CC1NC2=NC(=NC(=C2)C3=C(C(=CC=C3)Cl)Cl)N
其他名称	TH-588, TH 588
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	Warmed: 19 mg/mL (64.36 mM)
	Water	Insoluble
	Ethanol	Warmed: 1 mg/mL (3.38 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.88 mL	169.39 mL	338.79 mL
0.5 mM	6.78 mL	33.88 mL	67.76 mL
1 mM	3.39 mL	16.94 mL	33.88 mL
5 mM	0.68 mL	3.39 mL	6.78 mL

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