THZ1
THZ1 是一种新型的选择性且高效的共价 CDK7 抑制剂，其 IC50（结合亲和力）为 3.2 nM；能够抑制 Jurkat 细胞的增殖，IC50 为 50 nM。
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生物活性
| Discription | THZ1 is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) of 3.2 nM; inhibits Jurkat cell's proliferation with IC50 of 50 nM | |||||
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| Cell Research |
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产品信息
| 目录号 | A14192 |
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| 分子式 | C31H28ClN7O2 |
| 分子量 | 566.05 |
| CAS号 | 1604810-83-4 |
| SMILES | CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl |
| 其他名称 | THZ-1,THZ 1 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 96 mg/mL (150.24 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+45% PEG 300+ddH2O | 3 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.67 mL | 88.33 mL | 176.66 mL |
| 0.5 mM | 3.53 mL | 17.67 mL | 35.33 mL |
| 1 mM | 1.77 mL | 8.83 mL | 17.67 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.53 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
Keywords: 购买 THZ1 | THZ1 供应商 | THZ1 花费 | THZ1 生产商 | 订购 THZ1 | THZ1 代理商
| 购买 1604810-83-4 | 1604810-83-4 供应商 | 1604810-83-4 花费 | 1604810-83-4 生产商 | 订购 1604810-83-4 | 1604810-83-4 代理商