产品详情

生物活性

THZ1是一种新型的选择性强效共价CDK7抑制剂，IC50（结合亲和力）为3.2 nM。抑制Jurkat细胞的增殖，IC50为50 nM。

溶解度 *

In vitro (25°C)	DMSO	96 mg/mL (150.24 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+45% PEG 300+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.67 mL	88.33 mL	176.66 mL
0.5 mM	3.53 mL	17.67 mL	35.33 mL
1 mM	1.77 mL	8.83 mL	17.67 mL
5 mM	0.35 mL	1.77 mL	3.53 mL

*The above data is based on the productmolecular weight 566.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14192
作用机制	Inhibitor (抑制剂)
M. Wt	566.05
Formula	C31H28ClN7O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1604810-83-4
Synonyms	THZ-1,THZ 1
SMILES	CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl