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Tie2 kinase inhibitor是一种有效的选择性Tie2抑制剂,IC50为0.25μM。
靶点信息
Tie-2 | ||||
0.25 μM |
In vitro (25°C) | DMSO | 35 mg/mL (79.63 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 2% Cremophor EL, 2% N,N-dimethylacetamide | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.75 mL | 113.77 mL | 227.53 mL |
0.5 mM | 4.55 mL | 22.75 mL | 45.51 mL |
1 mM | 2.28 mL | 11.38 mL | 22.75 mL |
5 mM | 0.46 mL | 2.28 mL | 4.55 mL |
*The above data is based on the productmolecular weight 439.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A10932 |
---|---|
作用机制 | Inhibitor (抑制剂) |
M. Wt | 439.5 |
Formula | C26H21N3O2S |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 948557-43-5 |
SMILES | COC1=CC2=C(C=C1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)S(=O)C)C5=CC=NC=C5 |
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