Torin 2

Name: Torin 2
SKU: A11586

目录号: A11586

mTOR 抑制剂

Product Citations (1)

Torin 2 Chemical Structure

CAS NO. 1223001-51-1

Torin 2 是有效的选择性mTOR抑制剂 (IC50 = 2.1 nM)。在PI3K上显示mTOR的800倍细胞选择性（mTOR和PI3K的细胞EC50值分别为0.25和200 nM）。

库存：现货

规格	价格	数量
10 mg	￥ 770.00
25 mg	￥ 1,400.00
50 mg	￥ 2,310.00
100 mg	￥ 3,430.00
10mM * 1mL in DMSO	￥ 777.00

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生物活性

Torin 2 是有效的选择性mTOR抑制剂 (IC50 = 2.1 nM)。在PI3K上显示mTOR的800倍细胞选择性（mTOR和PI3K的细胞EC50值分别为0.25和200 nM）。

靶点信息

mTOR (p53?/? MEFs)	ATM (PC3 cells)	ATR (PC3 cells)	DNA-PK (PC3 cells)
0.25 nM	28 nM(EC50)	35 nM(EC50)	118 nM(EC50)

溶解度 *

In vitro (25°C)	DMSO	18 mg/mL (41.63 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	1.4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.13 mL	115.63 mL	231.27 mL
0.5 mM	4.63 mL	23.13 mL	46.25 mL
1 mM	2.31 mL	11.56 mL	23.13 mL
5 mM	0.46 mL	2.31 mL	4.63 mL

*The above data is based on the productmolecular weight 432.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11586
作用机制	Inhibitor (抑制剂)
M. Wt	432.4
Formula	C24H15F3N4O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1223001-51-1
Synonyms	Torin2
SMILES	C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F