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Membrane Transporters/Ion Channels

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  1. GSK-2193874
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    GSK-2193874

    Catalog No. A14201
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    TRPV4 blocker
    GSK2193874被确定为选择性的口服活性TRPV4阻滞剂，可通过重组TRPV4通道和天然内皮TRPV4电流抑制Ca(2+)流入。 了解更多
  2. A 967079
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    A 967079

    Catalog No. A12353
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    TRPA1 channel blocker
    A 967079是选择性TRPA1通道阻滞剂(人和大鼠TRPA1受体的IC50值分别为67和289 nM)。 了解更多
  3. Cannabichromene
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    Cannabichromene

    Catalog No. A15497
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    TRPA1 activatior/TRPM8 blocker
    Cannabichromene是一种主要的非精神植物大麻素，可抑制内源性大麻素失活并激活瞬时受体电位锚蛋白1（TRPA1）。内源性大麻素和TRPA1均可调节肠胃蠕动。 了解更多
  4. TCS 5861528
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    TCS 5861528

    Catalog No. A14126
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    TRPA1 channel blocker
    TCS 5861528是TRPA1通道阻滞剂和AITC和4-HNE诱发的钙流入的拮抗剂。 了解更多
  5. IEM 1754 Dihydrobromide
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    IEM 1754 Dihydrobromide

    Catalog No. A14010
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    AMPA Receptor Blocker
    IEM 1754 Dihydrobromide是AMPA受体的电压依赖性明渠阻断剂。 了解更多
  6. NPPB
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    NPPB

    Catalog No. A16981
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    chloride channel blocker
    NPPB是一种氯离子通道阻滞剂（IC50 = 80 nM），也被确定为GPR35激动剂。 了解更多
  7. Talniflumate
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    Talniflumate

    Catalog No. A13339
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    CaCC blocker
    Talniflumate是一种钙激活的氯离子通道（CaCC）（hCLCA1/mCLCA3）阻滞剂；在细胞培养和动物模型中减少粘蛋白的合成和释放。 了解更多
  8. E-4031 dihydrochloride
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    E-4031 dihydrochloride

    Catalog No. A12857
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    K+ channel blocker?
    E-4031 dihydrochloride是KV11.1（hERG）通道的选择性阻滞剂；禁止快速延迟整流器K+电流（IKr）。 了解更多
  9. JNJ 303
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    JNJ 303

    Catalog No. A20952
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    IKs blocker
    JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. 了解更多
  10. Cesium chloride
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    Cesium chloride

    Catalog No. A15341
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    Potassium channel blocker
    Cesium chloride是钾通道阻滞剂。抑制起搏器电流（If）和超极化激活的阳离子电流（Ih）。通过灭活GSK-3β来防止血清和钾缺乏的小脑颗粒神经元中caspase-3的激活和神经元凋亡。 了解更多
  11. TAK-438 (vonoprazan)
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    TAK-438 (vonoprazan)

    Catalog No. A11239
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    potassium-competitive acid Blocker
    TAK-438 (vonoprazan)是一种新型的钾竞争酸阻滞剂。 了解更多
  12. 4-Aminopyridine
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    4-Aminopyridine

    Catalog No. A17490
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    Potassium channel blocker
    Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. 了解更多
  13. PAP-1 (5-(4-Phenoxybutoxy)psoralen)
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    PAP-1 (5-(4-Phenoxybutoxy)psoralen)

    Catalog No. A11521
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    Kv1.3 blocker
    PAP-1 (5-(4-Phenoxybutoxy)psoralen) 是一种有效的，选择性的，口服活性的?Kv1.3?阻滞剂 (EC50=2 nM)。PAP-1 以使用依赖性方式阻止 Kv1.3，并通过优先绑定到通道的 C 型灭活状态来起作用。 了解更多
  14. ML418
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    ML418

    Catalog No. A18426
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    Kir7.1 potassium channels blocker
    ML418 is a selective, sub-micromolar pore blocker of Kir7.1 potassium channels. The inward rectifier potassium (Kir) channel Kir7.1 (KCNJ13) is a key regulator of melanocortin signaling in the brain, electrolyte homeostasis in the eye, and uterine muscle contractility during pregnancy. 了解更多
  15. TRAM-34
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    TRAM-34

    Catalog No. A12783
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    Potassium Channel Blocker
    TRAM-34是中等电导Ca2+激活的K+通道（KCa3.1）（Kd = 20 nM）的高度选择性阻滞剂。在KV，BKCa，KCa2，Na+，CRAC和Cl-通道上具有200-1500倍的选择性。抑制有丝分裂刺激对淋巴细胞的激活。 了解更多
  16. Amiloride HCl
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    Amiloride HCl

    Catalog No. A10064
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    Na+ channel blocker
    Amiloride HCl是一种Na+通道阻滞剂，还抑制TRPP3通道和Na+/H+交换剂（NHE）。 了解更多
  17. Procainamide HCl
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    Procainamide HCl

    Catalog No. A14240
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    Sodium channel blocker/DNMT 抑制剂
    Procainamide HCl是钠通道阻滞剂，又是DNA甲基转移酶抑制剂。 了解更多
  18. Encainide HCl
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    Encainide HCl

    Catalog No. A13898
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    Sodium channel blocker
    Encainide hydrochloride是一种钠通道阻滞剂，具有Ic类抗心律不齐的作用。Encainide是一种非手性抗心律失常药和苯甲酰苯胺衍生物。 了解更多
  19. Flecainide acetate
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    Flecainide acetate

    Catalog No. A15088
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    Cardiac Na+ channel blocker
    Flecainide acetate是1C类抗心律不齐药物，特别用于室上性心律失常的治疗；通过阻断心脏中的Nav1.5钠通道起作用，从而延长了心脏动作电位。 了解更多
  20. A 803467
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    A 803467

    Catalog No. A11234
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    Sodium channel Blocker
    A 803467是NaV1.8通道的选择性阻滞剂（hNaV1.8，hNaV1.3，hNaV1.7，hNaV1.5和hNaV1.2通道的IC50值分别为8、2450、6740、7340和7380 nM）。 了解更多
  21. Raxatrigine (GSK1014802)
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    Raxatrigine (GSK1014802)

    Catalog No. A13020
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    Sodium channel blocker
    Raxatrigine (GSK1014802)是一种新型的钠通道阻滞剂，是一种有效的抗惊厥药物。在大鼠中，GSK1014802（20-80 mg/kg p.o.）以剂量依赖的方式减轻了苯环利定（PCP）诱导的逆向学习障碍，这表明GSK1014802在治疗精神分裂症的认知潜力方面具有潜力。 GSK2还是人MAO-B的有效抑制剂，pIC50值为7.96，但不抑制人MAO-A。 了解更多
  22. Vernakalant HCl
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    Vernakalant HCl

    Catalog No. A15275
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    Ion channel blocker
    Vernakalant hydrochloride是一种研究性混合离子通道阻滞剂，可以以2至5 mg/kg的剂量终止人的急性心房纤颤（AF），并且与现有药物相比，对房颤的选择性更高。在抗心律不齐的治疗中。 了解更多
  23. Pilsicainide HCl
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    Pilsicainide HCl

    Catalog No. A16362
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    Sodium Channel Blocker
    Pilsicainide是一种水溶性的选择性Na+通道阻滞剂。 了解更多
  24. Orphenadrine citrate
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    Orphenadrine citrate

    Catalog No. A11712
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    NMDA receptor 拮抗剂
    Orphenadrine柠檬酸盐是NMDA受体拮抗剂，Ki为6.0μM，还是HERG钾离子通道阻断剂。 了解更多
  25. Ralfinamide mesylate
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    Ralfinamide mesylate

    Catalog No. A22002
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    Na+ channel blocker
    Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain. 了解更多
  26. QX 314 chloride
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    QX 314 chloride

    Catalog No. A13760
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    Sodium channel Blocker
    QX 314 chloride是利多卡因的膜不可渗透的季衍生物，一种电压激活的Na+通道阻滞剂。 了解更多
  27. Disopyramide
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    Disopyramide

    Catalog No. A13900
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    Sodium channel blocker
    Disopyramide是一种抗心律不齐药物（IA类）和钠通道阻滞剂。 了解更多
  28. Metaflumizone
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    Metaflumizone

    Catalog No. A18830
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    Sodium channel blocker
    Metaflumizone is a semicarbazone insecticide, acts as a potent sodium channel blocker. 了解更多
  29. NNC 55-0396
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    NNC 55-0396

    Catalog No. A15188
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    Calcium channel blocker
    NNC 55-0396是Mibefradil衍生物，是一种高度选择性的T型钙通道阻滞剂；分别在INS-1细胞中抑制Cav3.1 T型通道和HVA电流的IC50值为6.8和> 100μM。 了解更多
  30. Mibefradil dihydrochloride
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    Mibefradil dihydrochloride

    Catalog No. A12482
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    Calcium channel blocker
    Mibefradil dihydrochloride是钙通道阻滞剂，对T型Ca2+通道具有中等选择性，对T型和L型通道的IC50值分别为2.7 uM和18.6 uM。 了解更多
  31. Azelnidipine
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    Azelnidipine

    Catalog No. A11219
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    calcium channel blocker
    Azelnidipine是一种钙阻断剂，可减轻肝纤维化并可能增加抗氧化防御能力。可以减轻肝纤维化并可能增加抗氧化防御能力。 了解更多
  32. Nifedipine
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    Nifedipine

    Catalog No. A10643
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    L-type calcium channel blocker.
    Nifedipine是一种L型钙通道阻滞剂。 了解更多
  33. (S)-Amlodipine
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    (S)-Amlodipine

    Catalog No. A14935
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    Calcium channel blocker
    (S)-Amlodipine是氨氯地平的(S)-对映体，具有活性的二氢吡啶钙通道阻滞剂主要存在于(-)-异构体中。 了解更多
  34. Cilnidipine
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    Cilnidipine

    Catalog No. A10215
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    Calcium channel blocker
    Cilnidipine是提供血管平滑肌中L型电压门控钙通道和交感神经末梢N型钙通道的双重阻滞剂。 了解更多
  35. Cinnarizine
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    Cinnarizine

    Catalog No. A16455
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    calcium channel blocker
    Cinnarizine是哌嗪的药物衍生物，其特征在于抗组胺药和钙通道阻滞剂。 了解更多
  36. Nilvadipine (ARC029)
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    Nilvadipine (ARC029)

    Catalog No. A11731
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    calcium channel blocker
    Nilvadipine (ARC029)是一种钙通道阻滞剂（CCB），用于治疗高血压和慢性主要脑动脉阻塞。 了解更多
  37. NP118809
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    NP118809

    Catalog No. A15192
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    N-type calcium channel blocker
    NP118809是有效的N型钙通道阻滞剂（IC50 = 0.11 uM）；对L型钙通道的选择性好。 了解更多
  38. Amlodipine
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    Amlodipine

    Catalog No. A10068
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    L-type calcium channel blocker
    Amlodipine是一种L型钙通道阻滞剂，具有降压作用。它抑制去极化大鼠主动脉中Ca2 +诱导的收缩（IC50 = 1.9 nM），并在心血管疾病中显示出血管保护作用。 了解更多
  39. NS6180
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    NS6180

    Catalog No. A12405
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    K(Ca) 3.1 channel blocker
    NS6180是一种新型有效的选择性KCa3.1通道抑制剂（IC50 = 9 nM），可防止T细胞活化和炎症反应。 了解更多
  40. Isradipine
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    Isradipine

    Catalog No. A10487
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    calcium channel blocker
    伊拉地平是二氢吡啶类钙通道阻滞剂。 了解更多
  41. Clevidipine
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    Clevidipine

    Catalog No. A11746
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    Calcium channel blocker
    Clevidipine是一种二氢吡啶类钙通道阻滞剂，用于在口服治疗不可行或不理想时降低血压。 了解更多
  42. ABT-639
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    ABT-639

    Catalog No. A12330
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    T-type Ca2+ channel blocker
    ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. 了解更多
  43. Berbamine
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    Berbamine

    Catalog No. A14794
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    Calcium channel blocker
    Berbamine是钙通道阻滞剂。 了解更多
  44. Amlodipine besylate (Norvasc)
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    Amlodipine besylate (Norvasc)

    Catalog No. A10069
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    L-type calcium channel blocker
    Amlodipine besylate是一种L型钙通道阻滞剂，具有降压作用。它抑制去极化大鼠主动脉中Ca2 +诱导的收缩（IC50 = 1.9 nM）。 了解更多
  45. ABT-639 hydrochloride
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    ABT-639 hydrochloride

    Catalog No. A12571
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    T-type Ca2+ channel blocker
    ABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca2+ channel blocker. 了解更多
  46. JTV-519 free base
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    JTV-519 free base

    Catalog No. A21846
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    Ca2+-dependent blocker
    TV-519 free base (K201 free base) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties. 了解更多
  47. Glyburide
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    Glyburide

    Catalog No. A10433
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    K+ channel and CFTR Cl- channel blocker
    Glyburide (Glibenclamide) 是一种抗糖尿病化合物，是一类磺脲类药物。 了解更多

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