Trk-IN-4
目录号: A19277
pan-Trk inhibitor
Trk-IN-4 (PF-6683324 异构体) 是一种在细胞测试中的强效 全Trk抑制剂,其半抑制浓度(IC50)分别为 TrkA 1.9 nM、TrkB 2.6 nM 和 TrkC 1.1 nM。具有抗高敏感性效果。
Discription | Trk-IN-4 (PF-6683324 isomer) is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect. | ||
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目录号 | A19277 |
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分子式 | C24H23F4N5O4 |
分子量 | 521.46 |
CAS号 | 1799788-94-5 |
SMILES | O=C(N)C1=C(O[C@H]2CCN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)C[C@H]2F)N=CC(C4=CN(C)C=N4)=C1 |
其他名称 | PF-6683324 isomer |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2