TVB-3664
目录号: A18829
FASN 抑制剂
TVB-3664 是一种口服可用、可逆、高效、选择性强且生物利用度高的脂肪酸合酶（FASN）抑制剂，其对人类和小鼠细胞棕榈酸合成的 IC50 值分别为 18 nM 和 12 nM。TVB-3664 显著降低了微管蛋白棕榈酰化和 mRNA 表达。
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生物活性
| Discription | TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor, with IC50 values of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively. TVB-3664 significantly reduces tubulin palmitoylation and mRNA expression. |
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产品信息
| 目录号 | A18829 |
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| 分子式 | C25H23F3N4O2 |
| 分子量 | 468.47 |
| CAS号 | 2097262-58-1 |
| SMILES | CC1=C(C=C(C(C)=C1)C(N2CC(C2)C3=CC=C(C=C3)C#N)=O)C4=C(N=C(N4)C(F)(F)F)COC |
| 其他名称 | TVB-3664; TVB 3664; TVB3664. |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 86 mg/mL (183.57 mM) | |
| Water | Insoluble | ||
| Ethanol | 46 mg/mL (98.19 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.35 mL | 106.73 mL | 213.46 mL |
| 0.5 mM | 4.27 mL | 21.35 mL | 42.69 mL |
| 1 mM | 2.13 mL | 10.67 mL | 21.35 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 2097262-58-1 | 2097262-58-1 供应商 | 2097262-58-1 花费 | 2097262-58-1 生产商 | 订购 2097262-58-1 | 2097262-58-1 代理商